Academic Journal
The causal effect of gut microbiota on hepatic encephalopathy: a mendelian randomization analysis
| العنوان: | The causal effect of gut microbiota on hepatic encephalopathy: a mendelian randomization analysis |
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| المؤلفون: | Jia-Lin Wu, Jun-Wei Chen, Ming-Sheng Huang, Xin-Yi Deng, Jia-Jun Deng, Tsz Yu Lau, Shi-Yu Cao, Hui-Ying Ran, Zai-Bo Jiang, Jun-Yang Luo |
| المصدر: | BMC Medical Genomics, Vol 17, Iss 1, Pp 1-7 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Internal medicine LCC:Genetics |
| مصطلحات موضوعية: | Mendelian randomization, Gut microbiota, Hepatic encephalopathy, Causal relationship, Gut-liver-brain axis, Internal medicine, RC31-1245, Genetics, QH426-470 |
| الوصف: | Abstract Background There is growing evidence for a relationship between gut microbiota and hepatic encephalopathy (HE). However, the causal nature of the relationship between gut microbiota and HE has not been thoroughly investigated. Method This study utilized the large-scale genome-wide association studies (GWAS) summary statistics to evaluate the causal association between gut microbiota and HE risk. Specifically, two-sample Mendelian randomization (MR) approach was used to identify the causal microbial taxa for HE. The inverse variance weighted (IVW) method was used as the primary MR analysis. Sensitive analyses were performed to validate the robustness of the results. Results The IVW method revealed that the genus Bifidobacterium (OR = 0.363, 95% CI: 0.139-0.943, P = 0.037), the family Bifidobacteriaceae (OR = 0.359, 95% CI: 0.133-0.950, P = 0.039), and the order Bifidobacteriales (OR = 0.359, 95% CI: 0.133-0.950, P = 0.039) were negatively associated with HE. However, no causal relationship was observed among them after the Bonferroni correction test. Neither heterogeneity nor horizontal pleiotropy was found in the sensitivity analysis. Conclusion Our MR study demonstrated a potential causal association between Bifidobacterium, Bifidobacteriaceae, and Bifidobacteriales and HE. This finding may provide new therapeutic targets for patients at risk of HE in the future. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1755-8794 |
| Relation: | https://doaj.org/toc/1755-8794 |
| DOI: | 10.1186/s12920-024-01939-y |
| URL الوصول: | https://doaj.org/article/9aa6e513ee0d401e8358e56871acca2f |
| رقم الانضمام: | edsdoj.9aa6e513ee0d401e8358e56871acca2f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17558794 |
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| DOI: | 10.1186/s12920-024-01939-y |