التفاصيل البيبلوغرافية
| العنوان: |
Advances in Atroposelectively De Novo Synthesis of Axially Chiral Heterobiaryl Scaffolds |
| المؤلفون: |
Xiaoke Zhang, Ya-Zhou Liu, Huawu Shao, Xiaofeng Ma |
| المصدر: |
Molecules, Vol 27, Iss 23, p 8517 (2022) |
| بيانات النشر: |
MDPI AG, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Organic chemistry |
| مصطلحات موضوعية: |
de novo synthesis, heterobiaryl, axially chiral, asymmetric synthesis, Organic chemistry, QD241-441 |
| الوصف: |
Axially chiral heterobiaryl frameworks are privileged structures in many natural products, pharmaceutically active molecules, and chiral ligands. Therefore, a variety of approaches for constructing these skeletons have been developed. Among them, de novo synthesis, due to its highly convergent and superior atom economy, serves as a promising strategy to access these challenging scaffolds including C-N, C-C, and N-N chiral axes. So far, several elegant reviews on the synthesis of axially chiral heterobiaryl skeletons have been disclosed, however, atroposelective construction of the heterobiaryl subunits by de novo synthesis was rarely covered. Herein, we summarized the recent advances in the catalytic asymmetric synthesis of the axially chiral heterobiaryl scaffold via de novo synthetic strategies. The related mechanism, scope, and applications were also included. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/27/23/8517; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules27238517 |
| URL الوصول: |
https://doaj.org/article/9a8c5a17506d4516b3649e5dd725f6d7 |
| رقم الانضمام: |
edsdoj.9a8c5a17506d4516b3649e5dd725f6d7 |
| قاعدة البيانات: |
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