التفاصيل البيبلوغرافية
| العنوان: |
Cancer detection rate of prebiopsy MRI with subsequent systematic and targeted biopsy are superior to non-targeting systematic biopsy without MRI in biopsy naïve patients: a retrospective cohort study |
| المؤلفون: |
Satoshi Washino, Shigeru Kobayashi, Tomohisa Okochi, Tomohiro Kameda, Tsuzumi Konoshi, Tomoaki Miyagawa, Tatsuya Takayama, Tatsuo Morita |
| المصدر: |
BMC Urology, Vol 18, Iss 1, Pp 1-8 (2018) |
| بيانات النشر: |
BMC, 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: |
Magnetic resonance imaging, Biopsy, Target, Random, Prostate cancer, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: |
Abstract Background To determine whether prebiopsy multiparametric magnetic resonance imaging (mpMRI) with subsequent systematic plus targeted biopsies for suspicious lesions improve prostate cancer detection compared with standard non-targeting systematic biopsies without mpMRI in biopsy-naïve patients. Methods Patients who underwent their first prostate biopsy due to suspicion of prostate cancer were analyzed retrospectively to compare the biopsy outcomes between patients who received prebiopsy mpMRI (215 patients) and those who did not (281 patients). mpMRI was performed to determine pre-biopsy likelihood of the presence of prostate cancer using a three-point scale (1 = low level of suspicion, 2 = equivocal, and 3 = high level of suspicion). Systematic biopsies were performed in both groups. Targeted biopsies were added for a high level of suspicious lesions on mpMRI. All biopsies were performed by transperineal biopsy technique. After biopsy, Prostate Imaging Reporting and Data System ver. 2 (PIRADS-2) scoring was performed to describe the mpMRI findings and predictive value of PIRADS-2 was evaluated. Results The detection rate of total and clinically significant prostate cancer was significantly higher in patients who received prebiopsy mpMRI than in those who did not (55.3 and 46.0% vs. 42.0 and 35.2%, respectively; p = 0.004 and p = 0.016). The clinically insignificant prostate cancer detection rate was similar between the two groups (9.3% vs. 6.8%; p = 0.32). Of 86 patients who underwent systematic plus targeted biopsy in the MRI cohort and were diagnosed with prostate cancer, seven patients were detected by addition of targeted biopsy whereas 29 patients were missed by targeted biopsy but detected by systematic biopsy. There was a correlation between the PIRADS-2 and prostate cancer detection rate, and a receiver-operator curve analysis yielded an area under the curve of 0.801 (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2490 |
| Relation: |
http://link.springer.com/article/10.1186/s12894-018-0361-4; https://doaj.org/toc/1471-2490 |
| DOI: |
10.1186/s12894-018-0361-4 |
| URL الوصول: |
https://doaj.org/article/9a418fedbe424a419ae03b075a2f575e |
| رقم الانضمام: |
edsdoj.9a418fedbe424a419ae03b075a2f575e |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder