Academic Journal
Identified S100A9 as a target for diagnosis and treatment of ulcerative colitis by bioinformatics analysis
| العنوان: | Identified S100A9 as a target for diagnosis and treatment of ulcerative colitis by bioinformatics analysis |
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| المؤلفون: | Lulu Tan, Xin Li, Hong Qin, Qingqing Zhang, Jinfeng Wang, Tao Chen, Chengwu Zhang, Xiaoying Zhang, Yuyan Tan |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Ulcerative colitis, Bioinformatics analysis, Immune infiltration, Diagnostic biomarkers, S100A9, Medicine, Science |
| الوصف: | Abstract Ulcerative colitis (UC) is a chronic, recurrent inflammatory bowel disease. UC confronts with severe challenges including the unclear pathogenesis and lack of specific diagnostic markers, demanding for identifying predictive biomarkers for UC diagnosis and treatment. We perform immune infiltration and weighted gene co-expression network analysis on gene expression profiles of active UC, inactive UC, and normal controls to identify UC related immune cell and hub genes. Neutrophils, M1 macrophages, activated dendritic cells, and activated mast cells are significantly enriched in active UC. MMP-9, CHI3L1, CXCL9, CXCL10, CXCR2 and S100A9 are identified as hub genes in active UC. Specifically, S100A9 is significantly overexpressed in mice with colitis. The receiver operating characteristic curve demonstrates the excellent performance of S100A9 expression in diagnosing active UC. Inhibition of S100A9 expression reduces DSS-induced colonic inflammation. These identified biomarkers associated with activity in UC patients enlighten the new insights of UC diagnosis and treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-55944-3 |
| URL الوصول: | https://doaj.org/article/c9969b305f04448c86098649565cbce2 |
| رقم الانضمام: | edsdoj.9969b305f04448c86098649565cbce2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-55944-3 |