التفاصيل البيبلوغرافية
| العنوان: |
The dermato-protective effects of lucidone from Lindera erythrocarpa through the induction of Nrf2-mediated antioxidant genes in UVA-irradiated human skin keratinocytes |
| المؤلفون: |
You-Cheng Hseu, Yu-Cheng Tsai, Pei-Jane Huang, Ting-Tsz Ou, Mallikarjuna Korivi, Li-Sung Hsu, Show-Huei Chang, Chi-Rei Wu, Hsin-Ling Yang |
| المصدر: |
Journal of Functional Foods, Vol 12, Iss , Pp 303-318 (2015) |
| بيانات النشر: |
Elsevier, 2015. |
| سنة النشر: |
2015 |
| المجموعة: |
LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: |
Lucidone, Lindera erythrocarpa, UVA, ROS, Nrf2, Nutrition. Foods and food supply, TX341-641 |
| الوصف: |
This study investigated the dermato-protective effects of lucidone, a cyclopentenedione from Lindera erythrocarpa dried fruits, against UVA-induced oxidative stress and apoptosis in human keratinocytes (HaCaT). Pre-treatment with lucidone (1–4 µM) significantly protects keratinocytes from UVA (15 J/cm2)-induced cell death, excessive ROS generation, LDH release, lipid peroxidation, and DNA damage. Notably, lucidone inhibited the UVA-induced apoptosis of HaCaT cells as measured by a reduction of DNA fragmentation, mitochondria dysfunction, and Bcl-2/Bax dysregulation. Furthermore, antioxidant potential of lucidone was directly correlated with the induction of antioxidant genes, including HO-1, NQO-1, and γ-GCLC by transcriptional activation of Nrf2. Treatment with hydrogen peroxide showed cellular byproducts of UVA irradiation-induced cell death, LDH release, and ROS generation, but these phenomena were inhibited by pre-treatment of lucidone. Besides, in Nrf2 knock-down cells, lucidone failed to protect UVA-induced oxidative stress or cell death. Our findings suggest that lucidone is capable of protecting skin cells from UVA-irradiated damage. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1756-4646 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1756464614003259; https://doaj.org/toc/1756-4646 |
| DOI: |
10.1016/j.jff.2014.10.019 |
| URL الوصول: |
https://doaj.org/article/993aa40624da404e9ae593fb8e120e6a |
| رقم الانضمام: |
edsdoj.993aa40624da404e9ae593fb8e120e6a |
| قاعدة البيانات: |
Directory of Open Access Journals |