Academic Journal
Impact of Iron Supplementation on the State of Oxidative Stress in Pregnant Women Suffering from Iron-deficient Anemia
| العنوان: | Impact of Iron Supplementation on the State of Oxidative Stress in Pregnant Women Suffering from Iron-deficient Anemia |
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| المؤلفون: | Abdulkareem M. Jewad, Ali A. H. Albakaa, Warqaa S. Khalaf, Ameer J. Shwayel |
| المصدر: | Journal of Applied Hematology, Vol 15, Iss 3, Pp 197-203 (2024) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | anti-oxidant, iron supplementation, iron-deficiency anemia, oxidative stress, pregnant women, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background: The majority of pregnant women suffer from iron deficiency anemia (IDA). In addition to affecting hematological parameters, IDA disrupts the body’s oxidative balance, which impairs pregnancy outcome. OBJECTIVE: The objective is to determine the impact of orally supplementation of ferrous sulfate on pregnant women with IDA on their antioxidant levels and oxidative stress (OS) status. MATERIALS AND METHODS: This case–control study population comprised 60 pregnant women, divided into two categories: 30 pretreated pregnant women with IDA and 30 posttreatment pregnant women after 6–8 weeks with ferrous sulfate 200 mg daily. We also included 30 nonanemic, nonpregnant women as a healthy control group. We measured the antioxidant parameters: total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GPx), and the malondialdehyde (MDA) oxidant parameter for all groups. Results: The results revealed significant decreases in each of hemoglobin (HB), iron, ferritin, TAC, GPx, and SOD, as well as a significant increase in MDA levels (P < 0.000) in the pretreated IDA patients compared to the control group. The oxidant-antioxidant indices TAC, SOD, GPx, and MDA got a lot better after being treated with 200 mg/day of ferrous sulfate for 6–8 weeks. All of the study’s biomarkers showed a positive correlation with the level of HB. Conclusion: Oxidative stress has been associated with iron-deficient anemia. Supplementation with ferrous sulfate 200 mg is necessary for reducing the resulting OS. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1658-5127 2454-6976 |
| Relation: | https://journals.lww.com/10.4103/joah.joah_61_24; https://doaj.org/toc/1658-5127; https://doaj.org/toc/2454-6976 |
| DOI: | 10.4103/joah.joah_61_24 |
| DOI: | 10.4103/joah.joah_74_24 |
| URL الوصول: | https://doaj.org/article/98efb6c06ff644dba66e7317f46ea579 |
| رقم الانضمام: | edsdoj.98efb6c06ff644dba66e7317f46ea579 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 16585127 24546976 |
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| DOI: | 10.4103/joah.joah_61_24 |