التفاصيل البيبلوغرافية
| العنوان: |
Molecular and Evolutionary Characteristics of Chicken Parvovirus (ChPV) Genomes Detected in Chickens with Runting–Stunting Syndrome |
| المؤلفون: |
Ruy D. Chacón, Christian J. Sánchez-Llatas, Antonio Charlys da Costa, Stefhany Valdeiglesias Ichillumpa, Pablo Cea-Callejo, Obert Marín-Sánchez, Claudete S. Astolfi-Ferreira, Silvana Santander-Parra, Luis F. N. Nuñez, Antonio J. Piantino Ferreira |
| المصدر: |
Viruses, Vol 16, Iss 9, p 1389 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
Aveparvovirus, runting–stunting syndrome, viral metagenomics, phylogenetic analysis, selective pressure, protein modeling, Microbiology, QR1-502 |
| الوصف: |
Chicken Parvovirus (ChPV) belongs to the genus Aveparvovirus and is implicated in enteric diseases like runting–stunting syndrome (RSS) in poultry. In RSS, chicken health is affected by diarrhea, depression, and increased mortality, causing significant economic losses in the poultry industry. This study aimed to characterize the ChPV genomes detected in chickens with RSS through a metagenomic approach and compare the molecular and evolutionary characteristics within the Aveparvovirus galliform1 species. The intestinal content of broiler flocks affected with RSS was submitted to viral metagenomics. The assembled prevalent genomes were identified as ChPV after sequence and phylogenetic analysis, which consistently clustered separately from Turkey Parvovirus (TuPV). The strain USP-574-A presented signs of genomic recombination. The selective pressure analysis indicated that most of the coding genes in A. galliform1 are evolving under diversifying (negative) selection. Protein modeling of ChPV and TuPV viral capsids identified high conservancy over the VP2 region. The prediction of epitopes identified several co-localized antigenic peptides from ChPV and TuPV, especially for T-cell epitopes, highlighting the immunological significance of these sites. However, most of these peptides presented host-specific variability, obeying an adaptive scenario. The results of this study show the evolutionary path of ChPV and TuPV, which are influenced by diversifying events such as genomic recombination and selective pressure, as well as by adaptation processes, and their subsequent immunological impact. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1999-4915 |
| Relation: |
https://www.mdpi.com/1999-4915/16/9/1389; https://doaj.org/toc/1999-4915 |
| DOI: |
10.3390/v16091389 |
| URL الوصول: |
https://doaj.org/article/d98bc546bff545bbba655393cacb46c2 |
| رقم الانضمام: |
edsdoj.98bc546bff545bbba655393cacb46c2 |
| قاعدة البيانات: |
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