التفاصيل البيبلوغرافية
| العنوان: |
Pathophysiological Correlation between Cigarette Smoking and Amyotrophic Lateral Sclerosis |
| المؤلفون: |
Spiro Menounos, Philip M. Hansbro, Ashish D. Diwan, Abhirup Das |
| المصدر: |
NeuroSci, Vol 2, Iss 2, Pp 120-134 (2021) |
| بيانات النشر: |
MDPI AG, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
amyotrophic lateral sclerosis (ALS), motor neuron degeneration, cigarette smoking, oxidative stress, neuroinflammation, immunometabolism, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
Cigarette smoke (CS) has been consistently demonstrated to be an environmental risk factor for amyotrophic lateral sclerosis (ALS), although the molecular pathogenic mechanisms involved are yet to be elucidated. Here, we propose different mechanisms by which CS exposure can cause sporadic ALS pathogenesis. Oxidative stress and neuroinflammation are widely implicated in ALS pathogenesis, with blood–spinal cord barrier disruption also recognised to be involved in the disease process. In addition, immunometabolic, epigenetic and microbiome alterations have been implicated in ALS recently. Identification of the underlying pathophysiological mechanisms that underpin CS-associated ALS will drive future research to be conducted into new targets for treatment. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2673-4087 |
| Relation: |
https://www.mdpi.com/2673-4087/2/2/8; https://doaj.org/toc/2673-4087 |
| DOI: |
10.3390/neurosci2020008 |
| URL الوصول: |
https://doaj.org/article/9861c47cfd704c3ea9042def5bb6a99a |
| رقم الانضمام: |
edsdoj.9861c47cfd704c3ea9042def5bb6a99a |
| قاعدة البيانات: |
Directory of Open Access Journals |