Academic Journal
Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury
| العنوان: | Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury |
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| المؤلفون: | Suat Kamisli, Cenk Basaran, Kadir Batcioglu, Mustafa Namık Oztanir, Mehmet Gul, Basri Satilmis, Ayse Burcin Uyumlu, Basak Kayhan, Metin Genc |
| المصدر: | Archives of Medical Science, Vol 15, Iss 2, Pp 467-474 (2019) |
| بيانات النشر: | Termedia Publishing House, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | brain injury, neuroprotection, global cerebral ischemia, sodium channels, Medicine |
| الوصف: | Introduction RS100642, a mexiletine analogue, is a novel sodium channel blocker with neuroprotective and antioxidant activities. The protectivity of RS100642, which has been shown against focal cerebral ischemia, was investigated in global cerebral ischemia in this study. Material and methods Global cerebral ischemia was induced for five minutes in adult male Wistar Albino rats via the 4-vessel occlusion method. Intravenous administration of 1 mg/kg RS100642 following reperfusion for 30 min (RS100642 group) was compared with a sham treatment group (ischemia group) and nonischemized group (control) histologically based on morphology and caspase-3 immunohistochemistry, and biochemically based both on measurement of oxidative stress including malondialdehyde (MDA) levels, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities and on assessment of apoptosis including caspase-3 and -8 activities and tumor necrosis factor α (TNF-α) levels at the end of 6 h. Results While the RS100642 group had significantly lower MDA levels and higher SOD activities than the sham treatment group (p 0.05) and significantly lower than those of the controls (p < 0.05). Necrosis and caspase-3 activity and immunoreactivity in the RS100642 group were significantly lower than those in the sham treatment group (p 0.05). Conclusions Na + channel blockade by RS100642 has remarkable neuroprotective effects following global brain ischemia/reperfusion damage. Further research is required to determine the optimum dose and time of administration. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1734-1922 1896-9151 |
| Relation: | https://www.archivesofmedicalscience.com/Neuroprotective-effects-of-the-new-Na-channel-blocker-rs100642-in-global-ischemic,70491,0,2.html; https://doaj.org/toc/1734-1922; https://doaj.org/toc/1896-9151 |
| DOI: | 10.5114/aoms.2017.72550 |
| URL الوصول: | https://doaj.org/article/982fd01b4dc44f8691c5ad95b59e2f08 |
| رقم الانضمام: | edsdoj.982fd01b4dc44f8691c5ad95b59e2f08 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17341922 18969151 |
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| DOI: | 10.5114/aoms.2017.72550 |