التفاصيل البيبلوغرافية
| العنوان: |
Lidocaine promotes apoptosis in breast cancer cells by affecting VDAC1 expression |
| المؤلفون: |
Dingde Long, Xingjun Fang, Peihua Yuan, Liqin Cheng, Hongtao Li, LiangChao Qu |
| المصدر: |
BMC Anesthesiology, Vol 22, Iss 1, Pp 1-9 (2022) |
| بيانات النشر: |
BMC, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Anesthesiology |
| مصطلحات موضوعية: |
Lidocaine, Voltage-dependent anion channel 1, Invasive breast cancer, Apoptosis, Anesthesiology, RD78.3-87.3 |
| الوصف: |
Abstract Objective To investigate the effect of lidocaine on the expression of voltage-dependent anion channel 1 (VDAC1) in breast invasive carcinoma (BRCA) and its impact on the apoptosis of breast cancer cells. Methods We collected clinical data from patients with invasive breast cancer from 2010 to 2020 in the First affiliated hospital of Nanchang University, evaluated the prognostic value of VDAC1 gene expression in breast cancer, and detected the expression of VDAC1 protein in breast cancer tissues and paracancerous tissues by immunohistochemical staining of paraffin sections. Also, we cultured breast cancer cells (MCF-7) to observe the effect of lidocaine on the apoptosis of MCF-7 cells. Results Analysis of clinical data and gene expression data of BRCA patients showed VDAC1 was a differentially expressed gene in BRCA, VDAC1 may be of great significance for the diagnosis and prognosis of BRCA patients. Administration of lidocaine 3 mM significantly decreased VDAC1 expression, the expression of protein Bcl-2 was significantly decreased (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2253 |
| Relation: |
https://doaj.org/toc/1471-2253 |
| DOI: |
10.1186/s12871-022-01818-y |
| URL الوصول: |
https://doaj.org/article/97d75e20998440748a2a84fab3144c42 |
| رقم الانضمام: |
edsdoj.97d75e20998440748a2a84fab3144c42 |
| قاعدة البيانات: |
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