Academic Journal
Resting-state Fronto-limbic Connectivity in Unipolar Depressive Patients as a Predictor for Sporadic Conversion to (Hypo)mania
| العنوان: | Resting-state Fronto-limbic Connectivity in Unipolar Depressive Patients as a Predictor for Sporadic Conversion to (Hypo)mania |
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| المؤلفون: | I. Tajioui, T. van Neerven, M. J. van Tol, J. M. Bas-Hoogendam, D. Veltman, N. van der Wee, M. de Leeuw |
| المصدر: | European Psychiatry, Vol 66, Pp S699-S699 (2023) |
| بيانات النشر: | Cambridge University Press, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Psychiatry |
| مصطلحات موضوعية: | Psychiatry, RC435-571 |
| الوصف: | Introduction Patients with a bipolar disorder (BD) may experience one or several episodes of major depression before transitioning into a manic phase. Given that treatment with common antidepressants may exacerbate symptoms of mania in patients with BD, initial diagnosis of major depressive disorder (MDD) is a significant issue affecting BD patients. Currently, a family history of BD is used as an early identifier for BD, but as genetic factors associated with BD confer susceptibility to a wide range of psychiatric illnesses, this approach lacks specificity. Thus, there is a pressing need for a biomarker which specifically predicts development of bipolar symptoms in patients with MDD, rather than a trait vulnerability to psychiatric disorder Objectives The aim of this study is to assess alterations in fronto-limbic function that exist prior to the manifestation of the first manic episode in BD patients without familial predisposition for BD. Methods To identify a biomarker for conversion to BD we performed a study in a naturalistic sample of MDD patients without a familial risk for BD, which were followed for 9 years. We used a seed-based functional connectivity analysis to assess differences in resting-state fronto-limbic connectivity between MDD patients who converted to BD during the follow-up period (n = 11), and non-converting MDD patients (n = 56). Results Clusters of significantly reduced functional connectivity were found in the fronto-limbic network of prospective converters relative to non-converters. Conclusions Findings suggest that alterations of fronto-limbic functional connectivity during episodes of depression predate and associate with conversion to BD later in life, in the absence of familial risk. These fronto-limbic functional connectivity disturbances may be of interest for diagnosing early-stage BD, and may offer insight in the mechanisms that drive conversion in the absence of familial predisposition. Findings from this study need to be verified through large-scale longitudinal imaging studies in naturalistic cohorts of MDD patients. Disclosure of Interest None Declared |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0924-9338 1778-3585 |
| Relation: | https://www.cambridge.org/core/product/identifier/S0924933823014621/type/journal_article; https://doaj.org/toc/0924-9338; https://doaj.org/toc/1778-3585 |
| DOI: | 10.1192/j.eurpsy.2023.1462 |
| URL الوصول: | https://doaj.org/article/967788a6deb84028a93839e35cab8562 |
| رقم الانضمام: | edsdoj.967788a6deb84028a93839e35cab8562 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09249338 17783585 |
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| DOI: | 10.1192/j.eurpsy.2023.1462 |