Academic Journal
A study of comparison of PUVASOL and NBUVB in patients with vitiligo
| العنوان: | A study of comparison of PUVASOL and NBUVB in patients with vitiligo |
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| المؤلفون: | Vaaruni Ravishankar, Santoshdev P Rathod, Siddhartha Saikia, Raju G Chaudhary, Rekha B Solanki |
| المصدر: | Pigment International, Vol 5, Iss 2, Pp 96-102 (2018) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Dermatology |
| مصطلحات موضوعية: | NBUVB, phototherapy, psoralen, PUVASOL, vitiligo, Dermatology, RL1-803 |
| الوصف: | Introduction: Vitiligo is an acquired, hypomelanotic disease, characterized by circumscribed depigmented macules. Phototherapy, which is the use of ultraviolet irradiation with or without exogenous photosensitizer is a well established treatment option. Psoralens with sunlight as the source of ultraviolet A-rays is known as PUVASOL. Narrow band Ultraviolet B phototherapy (NBUVB; 311–313 nm) has been introduced over the past decade. Aims: To study the clinical effectiveness and assess the safety of NBUVB and PUVASOL therapy in Vitiligo patients. Methods: The patients were randomly allocated in to two groups containing 25 patients each. Group A patients received NBUVB with an initial dose of 250 mJ/cm2, incremented by 20% with each subsequent visit till optimum dose was achieved, twice a week on non-consecutive days. Group B patients received PUVASOL-oral Trimethylpsoralen or topical 0.2% w/w Trioxsalen followed by exposure to sunlight, twice a week on non-consecutive days. The extent of repigmentation was documented at regular intervals upto 6 months. Results: Amongst patients receiving NBUVB and PUVASOL, 56% and 48% had ≥50% repigmentation respectively. Disease was unstable in 48% and 36% of patients prior to commencement of therapy which reduced to 12% and 16% after therapy, respectively. 16% and 36% of the patients experienced side effects and 76% and 48% showed excellent colour match of the repigmented patches respectively. Conclusion: While both PUVASOL and NBUVB are both good therapeutic options; NBUVB therapy is found to be more effective and more cosmetically acceptable, with better colour matching of lesions and minimal adverse effects. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2349-5847 2349-5782 |
| Relation: | http://www.pigmentinternational.com/article.asp?issn=2349-5847;year=2018;volume=5;issue=2;spage=96;epage=102;aulast=Ravishankar; https://doaj.org/toc/2349-5847; https://doaj.org/toc/2349-5782 |
| DOI: | 10.4103/Pigmentinternational.Pigmentinternational_39_17 |
| URL الوصول: | https://doaj.org/article/c95fcafe4fc045b893fb93dc907684d8 |
| رقم الانضمام: | edsdoj.95fcafe4fc045b893fb93dc907684d8 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 23495847 23495782 |
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| DOI: | 10.4103/Pigmentinternational.Pigmentinternational_39_17 |