Academic Journal
Humulene Inhibits Acute Gastric Mucosal Injury by Enhancing Mucosal Integrity
| العنوان: | Humulene Inhibits Acute Gastric Mucosal Injury by Enhancing Mucosal Integrity |
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| المؤلفون: | Dahee Yeo, Su-Jung Hwang, Ye-Seul Song, Hyo-Jong Lee |
| المصدر: | Antioxidants, Vol 10, Iss 5, p 761 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | α-humulene, gastritis, histamine, antioxidant, cytokine, mucins, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | This study was designed to determine whether α-humulene, a major constituent in many plants used in fragrances, has a protective role against gastric injury in vivo and in vitro. A rat model of hydrochloric acid (HCl)/ethanol-induced gastritis and human mast cells (HMC-1) were used to investigate the mucosal protective effect of α-humulene. α-Humulene significantly inhibited gastric lesions in HCl/ethanol-induced acute gastritis and decreased gastric acid secretion pyloric ligation-induced gastric ulcers in vivo. In addition, α-humulene reduced the amount of reactive oxygen species and malondialdehyde through upregulation of prostaglandin E2 (PGE2) and superoxide dismutase (SOD). In HMC-1 cells, α-humulene decreased intracellular calcium and increased intracellular cyclic adenosine monophosphate (cAMP) levels, resulting in low histamine levels. α-Humulene also reduced the expression levels of cytokine genes such as interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF) by downregulating nuclear factor-κB (NF-κB) nuclear translocation. Finally, α-humulene upregulated the expression levels of mucin 5AC (Muc5ac), Muc6, trefoil factor 1 (Tff1), trefoil factor 2 (Tff2), and polymeric immunoglobulin receptor (pigr). α-Humulene may attenuate HCl/ethanol-induced gastritis by inhibiting histamine release and NF-κB activation and stimulating antioxidants and mucosal protective factors, particularly Muc5ac and Muc6. Therefore, these data suggest that α-humulene is a potential drug candidate for the treatment of stress-induced or alcoholic gastritis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2076-3921 81034830 |
| Relation: | https://www.mdpi.com/2076-3921/10/5/761; https://doaj.org/toc/2076-3921 |
| DOI: | 10.3390/antiox10050761 |
| URL الوصول: | https://doaj.org/article/e95ef54f81034830b63c8365539b2261 |
| رقم الانضمام: | edsdoj.95ef54f81034830b63c8365539b2261 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20763921 81034830 |
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| DOI: | 10.3390/antiox10050761 |