التفاصيل البيبلوغرافية
| العنوان: |
Serum stratifin and presepsin as candidate biomarkers for early detection of COVID-19 disease progression |
| المؤلفون: |
Noriaki Arakawa, Shinichiro Matsuyama, Masaru Matsuoka, Isao Kitamura, Keiko Miyashita, Yutaro Kitagawa, Kazuo Imai, Kumiko Ogawa, Takuya Maeda, Yoshiro Saito, Chihiro Hasegawa |
| المصدر: |
Journal of Pharmacological Sciences, Vol 150, Iss 1, Pp 21-30 (2022) |
| بيانات النشر: |
Elsevier, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: |
COVID-19, Predictive biomarker, Stratifin, Presepsin, Therapeutics. Pharmacology, RM1-950 |
| الوصف: |
The prognosis of patients with severe cases of COVID-19 is poor; thus, biomarkers for earlier prediction of COVID-19 progression are vital. We measured levels of five lung injury-related biomarkers, SP-D, KL-6, presepsin, kallistatin and stratifin, in serum samples collected serially during hospitalization from 31 patients with mild/moderate or severe/critical COVID-19 pneumonia, and their predictive performances were compared. Like the previously reported presepsin, a new biomarker candidate, stratifin, was significantly elevated with the onset of severe or critical symptoms in COVID-19 patients and decreased with symptom improvement. Notably, changes in stratifin and presepsin levels were distinctly earlier than those in SP-D, KL-6 and even SpO2/FiO2 values. Furthermore, serum levels of these biomarkers were significantly higher at the pre-severe stage (before the start of oxygen support) of patients who eventually advanced to severe/critical stages than in the patients who remained at the mild/moderate stage. These results were confirmed in an independent cohort, including 71 mild/moderate and 14 severe/critical patients, for whom the performance of stratifin and presepsin in discriminating between mild/moderate and pre-severe conditions of COVID-19 patients was superior to that of the SpO2/FiO2 ratio. Therefore, we concluded that stratifin and presepsin could be used as prognostic biomarkers for severe COVID-19 progression. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1347-8613 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1347861322000470; https://doaj.org/toc/1347-8613 |
| DOI: |
10.1016/j.jphs.2022.06.002 |
| URL الوصول: |
https://doaj.org/article/950290dd22614200abf2e6e6d3336397 |
| رقم الانضمام: |
edsdoj.950290dd22614200abf2e6e6d3336397 |
| قاعدة البيانات: |
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