Academic Journal
Curcumin supplementation prevents cisplatin-induced nephrotoxicity: a randomized, double-blinded, and placebo-controlled trial
| العنوان: | Curcumin supplementation prevents cisplatin-induced nephrotoxicity: a randomized, double-blinded, and placebo-controlled trial |
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| المؤلفون: | Hasan Mehrab, Mehran Sharifi, Ali Akhavan, Mohammad-Hosein Aarabi, Marjan Mansourian, Elaheh Mosavi, Azadeh Moghaddas |
| المصدر: | Research in Pharmaceutical Sciences, Vol 18, Iss 6, Pp 648-662 (2023) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | clinical trial, cisplatin, curcumin, electrolyte, nephrotoxicity., Pharmacy and materia medica, RS1-441 |
| الوصف: | Background and purpose: Cisplatin-induced nephrotoxicity (CIN) remains the most prevailing unfavorable influence and may affect its clinical usage. This study sought to explore the possible impacts of curcumin on preventing CIN in human subjects. Clinical design: The investigation was a placebo-controlled, double-blinded, randomized clinical trial conducted on 82 patients receiving nano-curcumin (80 mg twice daily for five days) or an identical placebo with standard nephroprotective modalities against CIN. Data was gathered on patients' demographics, blood, urinary nitrogen, creatinine (Cr) levels, urinary electrolytes, and urine neutrophil gelatinase-associated lipocalin (NGAL) levels in treatment and placebo groups, 24 h and five days after initiating the administration of cisplatin. Findings/Results: Both investigation groups were alike considering the demographic characteristics and clinical baseline data. Curcumin administration led to a significant improvement in blood-urine nitrogen (BUN). BUN, Cr, glomerular filtration rate (GFR), and the ratio of NGAL-to-Cr considerably altered during the follow-up periods. However, the further alterations in other indices, including urinary sodium, potassium, magnesium, NGAL values, and potassium-to-Cr ratio were not statistically noteworthy. The significant differences in the NGAL-to-Cr ratio between the two groups may indicate the potential protective impact of curcumin supplementation against tubular toxicity. Curcumin management was safe and well-accepted; only insignificant gastrointestinal side effects were reported. Conclusion and implications: Curcumin supplementation may have the potential to alleviate CIN and urinary electrolyte wasting in cancer patients. Future research investigating the effects of a longer duration of follow-up, a larger participant pool, and a higher dosage of curcumin are recommended. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1735-5362 1735-9414 |
| Relation: | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2023;volume=18;issue=6;spage=648;epage=662;aulast=Mehrab; https://doaj.org/toc/1735-5362; https://doaj.org/toc/1735-9414 |
| DOI: | 10.4103/1735-5362.389952 |
| URL الوصول: | https://doaj.org/article/93d95c7d908f45268a5e562509f21253 |
| رقم الانضمام: | edsdoj.93d95c7d908f45268a5e562509f21253 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17355362 17359414 |
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| DOI: | 10.4103/1735-5362.389952 |