التفاصيل البيبلوغرافية
| العنوان: |
Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice |
| المؤلفون: |
Lauren M. Reynolds, Giovanni Hernandez, Del MacGowan, Christina Popescu, Dominique Nouel, Santiago Cuesta, Samuel Burke, Katherine E. Savell, Janet Zhao, Jose Maria Restrepo-Lozano, Michel Giroux, Sonia Israel, Taylor Orsini, Susan He, Michael Wodzinski, Radu G. Avramescu, Matthew Pokinko, Julia G. Epelbaum, Zhipeng Niu, Andrea Harée Pantoja-Urbán, Louis-Éric Trudeau, Bryan Kolb, Jeremy J. Day, Cecilia Flores |
| المصدر: |
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023) |
| بيانات النشر: |
Nature Portfolio, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
Abstract Initiating drug use during adolescence increases the risk of developing addiction or other psychopathologies later in life, with long-term outcomes varying according to sex and exact timing of use. The cellular and molecular underpinnings explaining this differential sensitivity to detrimental drug effects remain unexplained. The Netrin-1/DCC guidance cue system segregates cortical and limbic dopamine pathways in adolescence. Here we show that amphetamine, by dysregulating Netrin-1/DCC signaling, triggers ectopic growth of mesolimbic dopamine axons to the prefrontal cortex, only in early-adolescent male mice, underlying a male-specific vulnerability to enduring cognitive deficits. In adolescent females, compensatory changes in Netrin-1 protect against the deleterious consequences of amphetamine on dopamine connectivity and cognitive outcomes. Netrin-1/DCC signaling functions as a molecular switch which can be differentially regulated by the same drug experience as function of an individual’s sex and adolescent age, and lead to divergent long-term outcomes associated with vulnerable or resilient phenotypes. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-023-39665-1 |
| URL الوصول: |
https://doaj.org/article/93a05db18e6c46dd93f35c7f1605d302 |
| رقم الانضمام: |
edsdoj.93a05db18e6c46dd93f35c7f1605d302 |
| قاعدة البيانات: |
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