التفاصيل البيبلوغرافية
| العنوان: |
Risk stratification based on acute-on-chronic liver failure in cirrhotic patients hospitalized for acute variceal bleeding |
| المؤلفون: |
Zongyi Zhu, Huiqing Jiang |
| المصدر: |
BMC Gastroenterology, Vol 23, Iss 1, Pp 1-11 (2023) |
| بيانات النشر: |
BMC, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: |
Acute variceal bleeding, Acute-on-chronic liver failure, Risk stratification, Prognosis, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: |
Abstract Background and aims Acute variceal bleeding (AVB) is a life-threatening complication of cirrhosis. Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute decompensation of cirrhosis, multiple organ failures and high short-term mortality. This study aimed to evaluate the role of ACLF in the risk stratification of cirrhotic patients with AVB. Methods Prospective data of 335 cirrhotic patients hospitalized for AVB were retrospectively extracted from Medical Information Mart for Intensive Care (MIMIC)-IV database. ACLF was defined by European Association for the Study of Liver-Chronic Liver Failure Consortium and diagnosed/graded with chronic liver failure-organ failure (CLIF-OF) score. Cox-proportional hazards regression analysis was performed to identify the risk factors for 6-week morality in AVB patients. Discrimination and calibration of prognostic scores were evaluated by plotting the receiver operating characteristics (ROC) curve and calibration curve, respectively. Overall performance was assessed by calculating the Brier score and R2 value. Results A total of 181 (54.0%) patients were diagnosed with ACLF (grade 1: 18.2%, grade 2: 33.7%, grade 3: 48.1%) at admission. The 6-week mortality in patients with ACLF was significantly higher than that in patients without ACLF (43.6% vs. 8.4%, P |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-230X |
| Relation: |
https://doaj.org/toc/1471-230X |
| DOI: |
10.1186/s12876-023-02768-6 |
| URL الوصول: |
https://doaj.org/article/9389a97af5a24f53bd4992b037a38a30 |
| رقم الانضمام: |
edsdoj.9389a97af5a24f53bd4992b037a38a30 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder