Academic Journal
LRP4 LDLα repeats of astrocyte enhance dendrite arborization of the neuron
| العنوان: | LRP4 LDLα repeats of astrocyte enhance dendrite arborization of the neuron |
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| المؤلفون: | Min Yan, Amin Guo, Peng Chen, Hongyang Jing, Dongyan Ren, Yanzi Zhong, Yongqiang Wu, Erkang Fei, Xinsheng Lai, Suqi Zou, Shunqi Wang |
| المصدر: | Molecular Brain, Vol 13, Iss 1, Pp 1-12 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | LRP4, Ldlα repeats, Dendrite arborization, Pyramidal neuron, Golgi staining, Primary culture, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Abstract The low-density lipoprotein receptor-related protein 4 (LRP4) is essential for inducing the neuromuscular junction (NMJ) formation in muscle fibers, and LRP4 plays a critical role in dendritic development and synaptogenesis in the central nervous system (CNS). As a single transmembrane protein, LRP4 contains an enormously sizeable extracellular domain (ECD), containing multiple LDLα repeats in the N-terminal of ECD. LRP4 only with extracellular domain acts as a similar mechanism of full-length LRP4 in muscles to stimulate acetylcholine receptor clustering. In this study, we elucidated that LDLα repeats of LRP4 maintained the body weight and survival rate. Dendritic branches of the pyramidal neurons in Lrp4-null mice with LRP4 LDLα repeats residue were more than in Lrp4-null mice without residual LRP4 domain. Supplement with conditioned medium from LRP4 LDLα overexpression cells, the primary culture pyramidal neurons achieved strong dendritic arborization ability. Besides, astrocytes with LRP4 LDLα repeats residue could promote pyramidal neuronal dendrite arborization in the primary co-cultured system. These observations signify that LRP4 LDLα repeats play a prominent underlying role in dendrite arborization. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-6606 93148879 |
| Relation: | https://doaj.org/toc/1756-6606 |
| DOI: | 10.1186/s13041-020-00708-z |
| URL الوصول: | https://doaj.org/article/93148879446c4ebba41587b0a54866d8 |
| رقم الانضمام: | edsdoj.93148879446c4ebba41587b0a54866d8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17566606 93148879 |
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| DOI: | 10.1186/s13041-020-00708-z |