التفاصيل البيبلوغرافية
| العنوان: |
Synergistic Interactions of a Synthetic Lubricin-Mimetic with Fibronectin for Enhanced Wear Protection |
| المؤلفون: |
Roberto C. Andresen Eguiluz, Sierra G. Cook, Mingchee Tan, Cory N. Brown, Noah J. Pacifici, Mihir S. Samak, Lawrence J. Bonassar, David Putnam, Delphine Gourdon |
| المصدر: |
Frontiers in Bioengineering and Biotechnology, Vol 5 (2017) |
| بيانات النشر: |
Frontiers Media S.A., 2017. |
| سنة النشر: |
2017 |
| المجموعة: |
LCC:Biotechnology |
| مصطلحات موضوعية: |
lubricin-mimetic, fibronectin, wear protection, bottlebrush polymer, surface forces apparatus, Biotechnology, TP248.13-248.65 |
| الوصف: |
Lubricin (LUB), a major mucinous glycoprotein of mammalian synovial fluids, is believed to provide excellent lubrication to cartilage surfaces. Consequently, when joint disease or replacement leads to increased friction and surface damage in the joint, robust synthetic LUB alternatives that could be used therapeutically to improve lubrication and surface protection are needed. Here, we report the characterization of a lubricating multiblock bottlebrush polymer whose architecture was inspired by LUB, and we investigate the role of fibronectin (FN), a glycoprotein found in the superficial zone of cartilage, in mediating the tribological properties of the polymer upon shear between mica surfaces. Our surface forces apparatus (SFA) normal force measurements indicate that the lubricin-mimetic (mimLUB) could be kept anchored between mica surfaces, even under high contact pressures, when an intermediate layer of FN was present. Additional SFA friction measurements show that FN would also extend the wearless friction regime of the polymer up to pressures of 3.4 MPa while ensuring stable friction coefficients (μ ≈ 0.28). These results demonstrate synergistic interactions between mimLUB and FN in assisting the lubrication and wear protection of ideal (mica) substrates upon shear. Collectively, these findings suggest that our proposed mimLUB might be a promising alternative to LUB, as similar mechanisms could potentially facilitate the interaction between the polymer and cartilage surfaces in articular joints and prosthetic implants in vivo. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-4185 |
| Relation: |
http://journal.frontiersin.org/article/10.3389/fbioe.2017.00036/full; https://doaj.org/toc/2296-4185 |
| DOI: |
10.3389/fbioe.2017.00036 |
| URL الوصول: |
https://doaj.org/article/c92d838484044ccb8d9f34fe6f4d47da |
| رقم الانضمام: |
edsdoj.92d838484044ccb8d9f34fe6f4d47da |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder