Academic Journal
Mitochondrial reactive oxygen species modulate mosquito susceptibility to Plasmodium infection.
| العنوان: | Mitochondrial reactive oxygen species modulate mosquito susceptibility to Plasmodium infection. |
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| المؤلفون: | Renata L S Gonçalves, Jose Henrique M Oliveira, Giselle A Oliveira, John F Andersen, Marcus F Oliveira, Pedro L Oliveira, Carolina Barillas-Mury |
| المصدر: | PLoS ONE, Vol 7, Iss 7, p e41083 (2012) |
| بيانات النشر: | Public Library of Science (PLoS), 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Mitochondria perform multiple roles in cell biology, acting as the site of aerobic energy-transducing pathways and as an important source of reactive oxygen species (ROS) that modulate redox metabolism.We demonstrate that a novel member of the mitochondrial transporter protein family, Anopheles gambiae mitochondrial carrier 1 (AgMC1), is required to maintain mitochondrial membrane potential in mosquito midgut cells and modulates epithelial responses to Plasmodium infection. AgMC1 silencing reduces mitochondrial membrane potential, resulting in increased proton-leak and uncoupling of oxidative phosphorylation. These metabolic changes reduce midgut ROS generation and increase A. gambiae susceptibility to Plasmodium infection.We provide direct experimental evidence indicating that ROS derived from mitochondria can modulate mosquito epithelial responses to Plasmodium infection. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3399787?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0041083 |
| URL الوصول: | https://doaj.org/article/9296ce8a071641d3bf8ee784f31c9bb8 |
| رقم الانضمام: | edsdoj.9296ce8a071641d3bf8ee784f31c9bb8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0041083 |