Academic Journal
Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis
| العنوان: | Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis |
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| المؤلفون: | Shraddha Pai, Peipei Li, Bryan Killinger, Lee Marshall, Peixin Jia, Ji Liao, Arturas Petronis, Piroska E. Szabó, Viviane Labrie |
| المصدر: | Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
| بيانات النشر: | Nature Portfolio, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | Science |
| الوصف: | Dopamine dysregulation is centrally linked to major psychosis. Here, the authors characterise the hypomethylation of an enhancer within the insulin-like growth factor 2 gene in neurons of patients with major psychosis and provide evidence that this enhancer targets the tyrosine hydroxylase gene, responsible for dopamine synthesis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2041-1723 78740010 |
| Relation: | https://doaj.org/toc/2041-1723 |
| DOI: | 10.1038/s41467-019-09786-7 |
| URL الوصول: | https://doaj.org/article/92406a1645fa465a86fc451c78740010 |
| رقم الانضمام: | edsdoj.92406a1645fa465a86fc451c78740010 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20411723 78740010 |
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| DOI: | 10.1038/s41467-019-09786-7 |