Academic Journal
Sustained release of vancomycin from novel biodegradable nanofiber-loaded vascular prosthetic grafts: in vitro and in vivo study
| العنوان: | Sustained release of vancomycin from novel biodegradable nanofiber-loaded vascular prosthetic grafts: in vitro and in vivo study |
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| المؤلفون: | Liu KS, Lee CH, Wang YC, Liu SJ |
| المصدر: | International Journal of Nanomedicine, Vol 2015, Iss default, Pp 885-891 (2015) |
| بيانات النشر: | Dove Medical Press, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | Kuo-Sheng Liu,1 Cheng-Hung Lee,2 Yi-Chuan Wang,3 Shih-Jung Liu3 1Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan; 2Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan; 3Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan Abstract: This study describes novel biodegradable, drug-eluting nanofiber-loaded vascular prosthetic grafts that provide local and sustained delivery of vancomycin to surrounding tissues. Biodegradable nanofibers were prepared by first dissolving poly(D,L)-lactide-co-glycolide and vancomycin in 1,1,1,3,3,3-hexafluoro-2-propanol. The solution was then electrospun into nanofibers onto the surface of vascular prostheses. The in vitro release rates of the pharmaceutical from the nanofiber-loaded prostheses was characterized using an elution method and a high-performance liquid chromatography assay. Experimental results indicated that the drug-eluting prosthetic grafts released high concentrations of vancomycin in vitro (well above the minimum inhibitory concentration) for more than 30 days. In addition, the in vivo release behavior of the drug-eluting grafts implanted in the subcutaneous pocket of rabbits was also documented. The drug-eluting grafts developed in this work have potential applications in assisting the treatment of vascular prosthesis infection and resisting reinfection when an infected graft is to be exchanged. Keywords: drug-eluting prosthetic graft, vascular prosthesis infection, release characteristics |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1178-2013 92393063 |
| Relation: | http://www.dovepress.com/sustained-release-of-vancomycin-from-novel-biodegradable-nanofiber-loa-peer-reviewed-article-IJN; https://doaj.org/toc/1178-2013 |
| URL الوصول: | https://doaj.org/article/9239306392da42fab02d328d07d3dd09 |
| رقم الانضمام: | edsdoj.9239306392da42fab02d328d07d3dd09 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11782013 92393063 |
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