Academic Journal
Association of serum ferritin trends with liver enzyme patterns in β-thalassemia major: A longitudinal correlational study
| العنوان: | Association of serum ferritin trends with liver enzyme patterns in β-thalassemia major: A longitudinal correlational study |
|---|---|
| المؤلفون: | Samarth Mukesh Rabadiya, M Yogesh, Jay Nagda, Rohankumar Gandhi, Naresh Makwana |
| المصدر: | Journal of Family Medicine and Primary Care, Vol 13, Iss 7, Pp 2698-2702 (2024) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | ferritin, liver function tests, indian population, iron overload, thalassemia, Medicine |
| الوصف: | Background: β-Thalassemia major patients require lifelong blood transfusions, leading to iron overload and liver injury. This study examines the longitudinal association between serum ferritin and liver function over 5 years in pediatric patients. Methods: This retrospective study included 582 transfusion-dependent thalassemia patients aged 1–18 years. Serum ferritin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and albumin were measured annually. Correlation and linear regression analyses assessed associations between ferritin trajectories and liver enzymes. Results: Mean ferritin rose from 1820 ± 960 ng/mL at baseline to 4500 ± 1900 ng/mL at year 5, indicating worsening iron overload. AST and ALT levels also steadily climbed over follow-up, whereas albumin declined slightly. Ferritin correlated positively with AST (r = 0.675, P < 0.01) and ALT (r = 0.607, P < 0.01), but not with albumin (r = -0.143, P = 0.153) annually. The regression interaction term showed within-patient ferritin increases over time were independently associated with escalating AST and ALT (P < 0.05), after adjusting for confounders. Conclusion: Rising ferritin levels predict progressive liver injury in regularly transfused pediatric thalassemia patients. Tighter control of iron overload may help preserve hepatic function. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2249-4863 2278-7135 |
| Relation: | https://journals.lww.com/10.4103/jfmpc.jfmpc_1897_23; https://doaj.org/toc/2249-4863; https://doaj.org/toc/2278-7135 |
| DOI: | 10.4103/jfmpc.jfmpc_1897_23 |
| URL الوصول: | https://doaj.org/article/91cc8bba942848c3beff84430fa112c3 |
| رقم الانضمام: | edsdoj.91cc8bba942848c3beff84430fa112c3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22494863 22787135 |
|---|---|
| DOI: | 10.4103/jfmpc.jfmpc_1897_23 |