التفاصيل البيبلوغرافية
| العنوان: |
Therapeutic role of EGFR - Tyrosine kinase inhibitors in non-small cell lung cancer with leptomeningeal metastasis |
| المؤلفون: |
Caiyan Jia, Qian Xu, Lu Zhao, Fanming Kong, Yingjie Jia |
| المصدر: |
Translational Oncology, Vol 39, Iss , Pp 101832- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
Leptomeningeal metastasis, Epidermal growth factor receptor, EGFR tyrosine kinase inhibitors, Non-small cell lung cancer, Osimertinib, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Leptomeningeal metastasis (LM) is a significant complication that advances fast and has a poor prognosis for patients with advanced non-small cell lung cancer (NSCLC) who have epidermal growth factor receptor (EGFR) mutations. Current therapies for LM are inconsistent and ineffective, and established techniques such as radiation, chemotherapy, and surgery continue to fall short of potential outcomes. Nonetheless, EGFR tyrosine kinase inhibitors (TKIs) exhibit potent anti-tumor activity and hold considerable promise for NSCLC patients with EGFR mutations. Thus, assessing EGFR-TKIs effectiveness in treating these central nervous system (CNS) problems is crucial. This review integrates current literature on the intracranial efficacy of EGFR-TKIs to explore the varying impacts of approved EGFR-TKIs in LM patients and the therapeutic possibilities presented by other EGFR-TKIs in development. To delineate the optimal clinical treatment strategy, further exploration is needed regarding the optimal sequencing of EGFR-TKIs and the selection of alternative therapy options following initial treatment failure with EGFR-TKIs. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1936-5233 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1936523323002188; https://doaj.org/toc/1936-5233 |
| DOI: |
10.1016/j.tranon.2023.101832 |
| URL الوصول: |
https://doaj.org/article/d91cbe21c67245599042a48bcf1db0da |
| رقم الانضمام: |
edsdoj.91cbe21c67245599042a48bcf1db0da |
| قاعدة البيانات: |
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