Academic Journal
Acetate attenuates hypothalamic pyroptosis in experimentally induced polycystic ovarian syndrome
| العنوان: | Acetate attenuates hypothalamic pyroptosis in experimentally induced polycystic ovarian syndrome |
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| المؤلفون: | Kehinde S. Olaniyi, Shalom U. Agan, Stephanie E. Areloegbe, Isaiah W. Sabinari, Adesola A. Oniyide, Linus A. Enye, Adams O. Omoaghe, Adeshina O. Adekeye, Olusegun A. Adeoluwa |
| المصدر: | BMC Research Notes, Vol 17, Iss 1, Pp 1-10 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Biology (General) LCC:Science (General) |
| مصطلحات موضوعية: | Acetate, GABA, Hypothalamus, Insulin resistance, Pyroptosis, PCOS, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390 |
| الوصف: | Abstract This study hypothesized that SCFA, acetate impacts positively on hypothalamic pyroptosis and its related abnormalities in experimentally induced PCOS rat model, possibly through NrF2/HIF1-α modulation. Eight-week-old female Wister rats were divided into groups (n = 5), namely control, PCOS, acetate and PCOS + acetate groups. Induction of PCOS was performed by administering 1 mg/kg body weight of letrozole for 21 days. After PCOS confirmation, the animals were treated with 200 mg/kg of acetate for 6 weeks. Rats with PCOS were characterized with insulin resistance, leptin resistance, increased plasma testosterone as well as degenerated ovarian follicles. There was also a significant increase in hypothalamic triglyceride level, triglyceride-glucose index, inflammatory biomarkers (SDF-1 and NF-kB) and caspase-6 as well as plasma LH and triglyceride. A decrease was observed in plasma adiponectin, GnRH, FSH, and hypothalamic GABA with severe inflammasome expression in PCOS rats. These were accompanied by decreased level of NrF2/HIF1-α, and the alterations were reversed when treated with acetate. Collectively, the present results suggest the therapeutic impact of acetate on hypothalamic pyroptosis and its related comorbidity in PCOS, a beneficial effect that is accompanied by modulation of NrF2/HIF1-α. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-0500 |
| Relation: | https://doaj.org/toc/1756-0500 |
| DOI: | 10.1186/s13104-024-06921-6 |
| URL الوصول: | https://doaj.org/article/917bfa4ff6884dc9b5f18d7f16f17c80 |
| رقم الانضمام: | edsdoj.917bfa4ff6884dc9b5f18d7f16f17c80 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17560500 |
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| DOI: | 10.1186/s13104-024-06921-6 |