التفاصيل البيبلوغرافية
| العنوان: |
Secondary metabolites from the deep-sea derived fungus Aspergillus terreus MCCC M28183 |
| المؤلفون: |
Xiaomei Huang, Yichao Wang, Guangyu Li, Zongze Shao, Jinmei Xia, Jiang-Jiang Qin, Weiyi Wang |
| المصدر: |
Frontiers in Microbiology, Vol 15 (2024) |
| بيانات النشر: |
Frontiers Media S.A., 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
Aspergillus, secondary metabolites, cytotoxic, antibacterial, deep-sea, Microbiology, QR1-502 |
| الوصف: |
Aspergillus fungi are renowned for producing a diverse range of natural products with promising biological activities. These include lovastatin, itaconic acid, terrin, and geodin, known for their cholesterol-regulating, anti-inflammatory, antitumor, and antibiotic properties. In our current study, we isolated three dimeric nitrophenyl trans-epoxyamides (1–3), along with fifteen known compounds (4–18), from the culture of Aspergillus terreus MCCC M28183, a deep-sea-derived fungus. The structures of compounds 1–3 were elucidated using a combination of NMR, MS, NMR calculation, and ECD calculation. Compound 1 exhibited moderate inhibitory activity against human gastric cancer cells MKN28, while compound 7 showed similar activity against MGC803 cells, with both showing IC50 values below 10 μM. Furthermore, compound 16 exhibited moderate potency against Vibrio parahaemolyticus ATCC 17802, with a minimum inhibitory concentration (MIC) value of 7.8 μg/mL. This promising research suggests potential avenues for developing new pharmaceuticals, particularly in targeting specific cancer cell lines and combating bacterial infections, leveraging the unique properties of these Aspergillus-derived compounds. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-302X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmicb.2024.1361550/full; https://doaj.org/toc/1664-302X |
| DOI: |
10.3389/fmicb.2024.1361550 |
| URL الوصول: |
https://doaj.org/article/91596bd236ee42d18692644e721fd281 |
| رقم الانضمام: |
edsdoj.91596bd236ee42d18692644e721fd281 |
| قاعدة البيانات: |
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