Academic Journal
Harnessing the potential of mesenchymal stem cells–derived exosomes in degenerative diseases
| العنوان: | Harnessing the potential of mesenchymal stem cells–derived exosomes in degenerative diseases |
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| المؤلفون: | Hsiu-Jung Liao, Yi-Ping Yang, Yu-Hao Liu, Huan-Chin Tseng, Teh-Ia Huo, Shih-Hwa Chiou, Chih-Hung Chang |
| المصدر: | Regenerative Therapy, Vol 26, Iss , Pp 599-610 (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) LCC:Cytology |
| مصطلحات موضوعية: | Extracellular vesicles derived from mesenchymal stem cells (MSC-EVs), Osteoarthritis, Rheumatoid arthritis, Cardiovascular disease, Age-related macular degeneration, Alzheimer's disease, Medicine (General), R5-920, Cytology, QH573-671 |
| الوصف: | Mesenchymal stem cells (MSCs) have gained attention as a promising therapeutic approach in both preclinical and clinical osteoarthritis (OA) settings. Various joint cell types, such as chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and release extracellular vesicles (EVs), which subsequently influence the biological activities of recipient cells. Recently, extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have shown the potential to modulate various physiological and pathological processes through the modulation of cellular differentiation, immune responses, and tissue repair. This review explores the roles and therapeutic potential of MSC-EVs in OA and rheumatoid arthritis, cardiovascular disease, age-related macular degeneration, Alzheimer's disease, and other degenerative diseases. Notably, we provide a comprehensive summary of exosome biogenesis, microRNA composition, mechanisms of intercellular transfer, and their evolving role in the highlight of exosome-based treatments in both preclinical and clinical avenues. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-3204 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352320424001378; https://doaj.org/toc/2352-3204 |
| DOI: | 10.1016/j.reth.2024.08.001 |
| URL الوصول: | https://doaj.org/article/8fb74a452f7e4369bace234ea8befce8 |
| رقم الانضمام: | edsdoj.8fb74a452f7e4369bace234ea8befce8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23523204 |
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| DOI: | 10.1016/j.reth.2024.08.001 |