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Utilizing direct and indirect information to improve the COVID-19 vaccination booster scheduling

التفاصيل البيبلوغرافية
العنوان: Utilizing direct and indirect information to improve the COVID-19 vaccination booster scheduling
المؤلفون: Yotam Dery, Matan Yechezkel, Irad Ben-Gal, Dan Yamin
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Value of information, Vaccination, COVID-19, Transmission model, SEIR model, Medicine, Science
الوصف: Abstract Current global COVID-19 booster scheduling strategies mainly focus on vaccinating high-risk populations at predetermined intervals. However, these strategies overlook key data: the direct insights into individual immunity levels from active serological testing and the indirect information available either through sample-based sero-surveillance, or vital demographic, location, and epidemiological factors. Our research, employing an age-, risk-, and region-structured mathematical model of disease transmission—based on COVID-19 incidence and vaccination data from Israel between 15 May 2020 and 25 October 2021—reveals that a more comprehensive strategy integrating these elements can significantly reduce COVID-19 hospitalizations without increasing existing booster coverage. Notably, the effective use of indirect information alone can considerably decrease COVID-19 cases and hospitalizations, without the need for additional vaccine doses. This approach may also be applicable in optimizing vaccination strategies for other infectious diseases, including influenza.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-024-58690-8
URL الوصول: https://doaj.org/article/8fa92d1030804c02b41de4029008fae7
رقم الانضمام: edsdoj.8fa92d1030804c02b41de4029008fae7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-024-58690-8