التفاصيل البيبلوغرافية
| العنوان: |
Metal Complex Formation and Anticancer Activity of Cu(I) and Cu(II) Complexes with Metformin |
| المؤلفون: |
Sherin Abdelrahman, Mawadda Alghrably, Marcello Campagna, Charlotte Armgard Emma Hauser, Mariusz Jaremko, Joanna Izabela Lachowicz |
| المصدر: |
Molecules, Vol 26, Iss 16, p 4730 (2021) |
| بيانات النشر: |
MDPI AG, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Organic chemistry |
| مصطلحات موضوعية: |
metformin, copper complexes, diabetes, cancer, proliferation, protonation constants, Organic chemistry, QD241-441 |
| الوصف: |
Metformin has been used for decades in millions of type 2 diabetes mellitus patients. In this time, correlations between metformin use and the occurrence of other disorders have been noted, as well as unpredictable metformin side effects. Diabetes is a significant cancer risk factor, but unexpectedly, metformin-treated diabetic patients have lower cancer incidence. Here, we show that metformin forms stable complexes with copper (II) ions. Both copper(I)/metformin and copper(II)/metformin complexes form adducts with glutathione, the main intracellular antioxidative peptide, found at high levels in cancer cells. Metformin reduces cell number and viability in SW1222 and K562 cells, as well as in K562-200 multidrug-resistant cells. Notably, the antiproliferative effect of metformin is enhanced in the presence of copper ions. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/26/16/4730; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules26164730 |
| URL الوصول: |
https://doaj.org/article/a8f9abc4aca341668a19bd4f8b47f1db |
| رقم الانضمام: |
edsdoj.8f9abc4aca341668a19bd4f8b47f1db |
| قاعدة البيانات: |
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