التفاصيل البيبلوغرافية
| العنوان: |
Senescent T Cell Induces Brown Adipose Tissue 'Whitening' Via Secreting IFN-γ |
| المؤلفون: |
Xiao-Xi Pan, Kang-Li Yao, Yong-Feng Yang, Qian Ge, Run Zhang, Ping-Jin Gao, Cheng-Chao Ruan, Fang Wu |
| المصدر: |
Frontiers in Cell and Developmental Biology, Vol 9 (2021) |
| بيانات النشر: |
Frontiers Media S.A., 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
senescence, T cell, adipose tissue, preadipocyte, brown adipocyte differentiation, IFN-γ, Biology (General), QH301-705.5 |
| الوصف: |
Aging-associated chronic inflammation is a key contributing factor to a cluster of chronic metabolic disorders, such as cardiovascular disease, obesity, and type 2 diabetes. Immune cells particularly T cells accumulate in adipose tissue with advancing age, and there exists a cross talk between T cell and preadipocyte, contributing to age-related adipose tissue remodeling. Here, we compared the difference in morphology and function of adipose tissue between young (3-month-old) and old (18-month-old) mice and showed the phenomenon of brown adipose tissue (BAT) “whitening” in old mice. Flow cytometry analysis suggested an increased proportion of T cells in BAT of old mice comparing with the young and exhibited senescent characteristics. We take advantage of coculture system to demonstrate directly that senescent T cells inhibited brown adipocyte differentiation of preadipocytes in adipose tissue. Mechanistically, both in vitro and in vivo studies suggested that senescent T cells produced and released a higher level of IFN-γ, which plays a critical role in inhibition of preadipocyte-to-brown adipocyte differentiation. Taken together, the data indicate that senescent T cell-derived IFN-γ is a key regulator in brown adipocyte differentiation. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-634X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fcell.2021.637424/full; https://doaj.org/toc/2296-634X |
| DOI: |
10.3389/fcell.2021.637424 |
| URL الوصول: |
https://doaj.org/article/8f728be5c8b84284bf5228bcae5fbf24 |
| رقم الانضمام: |
edsdoj.8f728be5c8b84284bf5228bcae5fbf24 |
| قاعدة البيانات: |
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