التفاصيل البيبلوغرافية
| العنوان: |
NOTCH and Graft-Versus-Host Disease |
| المؤلفون: |
Mauro Di Ianni, Beatrice Del Papa, Stefano Baldoni, Ambra Di Tommaso, Bianca Fabi, Emanuela Rosati, Annalisa Natale, Stella Santarone, Paola Olioso, Gabriele Papalinetti, Raffaella Giancola, Patrizia Accorsi, Paolo Di Bartolomeo, Paolo Sportoletti, Franca Falzetti |
| المصدر: |
Frontiers in Immunology, Vol 9 (2018) |
| بيانات النشر: |
Frontiers Media S.A., 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
NOTCH, graft-versus-host disease, tolerance, graft-versus-leukemia, HSCT, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
In allogeneic hematopoietic stem cell transplantation, which is the major curative therapy for hematological malignancies, T cells play a key role in the development of graft-versus-host disease (GvHD). NOTCH pathway is a conserved signal transduction system that regulates T cell development and differentiation. The present review analyses the role of the NOTCH signaling as a new regulator of acute GvHD. NOTCH signaling could also represent a new therapeutic target for GvHD. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/article/10.3389/fimmu.2018.01825/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2018.01825 |
| URL الوصول: |
https://doaj.org/article/8f236388b87f4c4591b90c05041343c9 |
| رقم الانضمام: |
edsdoj.8f236388b87f4c4591b90c05041343c9 |
| قاعدة البيانات: |
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