التفاصيل البيبلوغرافية
| العنوان: |
Study protocol for the POPART study—Prophylactic Oropharyngeal surfactant for Preterm infants: A Randomised Trial |
| المؤلفون: |
Peter Doran, Marie Galligan, Madeleine Claire Murphy, Brenda Molloy, Rabia Hussain, Colm O'Donnell |
| المصدر: |
BMJ Open, Vol 10, Iss 7 (2020) |
| بيانات النشر: |
BMJ Publishing Group, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
Medicine |
| الوصف: |
Introduction Many preterm infants develop respiratory distress syndrome (RDS), a condition characterised by a relative lack of surfactant. Endotracheal surfactant therapy revolutionised the care of preterm infants in the 1990s. However, supporting newborns with RDS with continuous positive airway pressure (CPAP) and reserving endotracheal surfactant for those who develop respiratory failure despite CPAP yield better results than intubating all infants for surfactant. Half of preterm infants born before 29 weeks gestation initially managed with CPAP are intubated for surfactant. Intubation is difficult to learn and associated with adverse effects. Surfactant administration into the oropharynx has been reported in preterm animals and humans and may be effective. We wished to determine whether giving oropharyngeal surfactant at birth reduces the rate of endotracheal intubation for respiratory failure in preterm infants within 120 hours of birth.Methods and analysis Prophylactic Oropharyngeal surfactant for Preterm infants: A Randomised Trial (POPART, Eudract No. 2016-004198-41) is an investigator-led, unblinded, multicentre, randomised, parallel group, controlled trial. Infants are eligible if born at a participating centre before 29 weeks gestational age (GA) and there is a plan to offer intensive care. Infants are excluded if they have major congenital anomalies. Infants are randomised at birth to treatment with oropharyngeal surfactant (120 mg vial |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2044-6055 |
| Relation: |
https://bmjopen.bmj.com/content/10/7/e035994.full; https://doaj.org/toc/2044-6055 |
| DOI: |
10.1136/bmjopen-2019-035994 |
| URL الوصول: |
https://doaj.org/article/e8ecf7761cd34eb69d6e6224d022fa58 |
| رقم الانضمام: |
edsdoj.8ecf7761cd34eb69d6e6224d022fa58 |
| قاعدة البيانات: |
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