التفاصيل البيبلوغرافية
| العنوان: |
The Role of Extracellular Vesicles in Idiopathic Pulmonary Fibrosis Progression: An Approach on Their Therapeutics Potential |
| المؤلفون: |
Alma Aurora Ramírez-Hernández, Juan Manuel Velázquez-Enríquez, Jovito Cesar Santos-Álvarez, Armando López-Martínez, Edilburga Reyes-Jiménez, Gabriela Carrasco-Torres, Karina González-García, Verónica Rocío Vásquez-Garzón, Rafael Baltierrez-Hoyos |
| المصدر: |
Cells, Vol 11, Iss 4, p 630 (2022) |
| بيانات النشر: |
MDPI AG, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Cytology |
| مصطلحات موضوعية: |
extracellular vesicles, fibroblasts, macrophages, alveolar epithelial cells, mesenchymal stem cells, therapeutic, Cytology, QH573-671 |
| الوصف: |
Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial lung disease of unknown etiology. Different types of cells are involved in fibrogenesis, which is persistently physical and molecular stimulation, either directly or by interacting with bioactive molecules and extracellular vesicles (EVs). Current evidence suggests that EVs play an essential role in IPF development. EVs are released by a variety of cells, including fibroblasts, epithelial cells, and alveolar macrophages. In addition, EVs can transport bioactive molecules, such as lipids, proteins, and nucleic acids, which play a pivotal role in cellular communication. Several proposed mechanisms show that an acceptor cell can capture, absorb, or interact with EVs through direct fusion with the plasma membrane, ligand–receptor interaction, and endocytotic process, modifying the target cell. During fibrogenesis, the release of EVs is deregulated, increases the EVs amount, and the cargo content is modified. This alteration is closely associated with the maintenance of the fibrotic microenvironment. This review summarizes the current data on the participation of EVs secreted by the cells playing a critical role in IPF pathogenesis. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2073-4409 |
| Relation: |
https://www.mdpi.com/2073-4409/11/4/630; https://doaj.org/toc/2073-4409 |
| DOI: |
10.3390/cells11040630 |
| URL الوصول: |
https://doaj.org/article/8e27ff74b89949968546053d7c6023ba |
| رقم الانضمام: |
edsdoj.8e27ff74b89949968546053d7c6023ba |
| قاعدة البيانات: |
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