التفاصيل البيبلوغرافية
| العنوان: |
P-12 METHYL GROUP DONOR SUPPLEMENTATION IN A MetALD MODEL: REGULATION OF GUT MICROBIOTA AND METABOLIC PARAMETERS |
| المؤلفون: |
Carolina Díaz Canul, Angel Omar Vázquez Esqueda, Rebeca Rosas Campos, Rebeca Escutia Gutiérrez, Natalia Gómez Gómez, Monica Ibarra Hernández, Marina Galicia Moreno, Juan Armendáriz Borunda, Ana Sandoval Rodriguez |
| المصدر: |
Annals of Hepatology, Vol 29, Iss , Pp 101626- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Specialties of internal medicine |
| مصطلحات موضوعية: |
Specialties of internal medicine, RC581-951 |
| الوصف: |
Conflict of interest: No Introduction and Objectives: Patients who meet both MASLD (Metabolic dysfunction-associated steatotic liver disease) and alcohol-related fatty liver disease (ALD) criteria are categorized as having MetALD (Metabolic and alcohol-related liver disease) and its damage is characterized by metabolic dysfunction, gut dysbiosis and liver inflammation, resulting in steatosis and fibrosis. Methyl group donor supplementation in MASLD demonstrated metabolic benefits; we expect to corroborate those effects in MetALD and look for microbiota changes induced by methyl availability. Patients / Materials and Methods: Twenty-four C57BL/6J male mice (25 ± 2g) were randomly assigned to 1) Control group (ND n=8); 2) MetALD (20% ethanol in water + 45% fat diet); 3) MetALD + MetMix (MetALD + methyl donors: methionine, betaine, zinc sulfate, choline, B9, B6 and B12). Each group maintained their respective diet/supplementation for 20 weeks. Liver, epididymal fat and body weight were weighted at sacrifice and liver enzymes, adipokines and lipid profile were measured on serum. Histopathological evaluation was performed on liver, adipose and colon tissues. Gene expression of IL6 and TNF-α was analyzed, while 16S rRNA gene sequencing in fecal DNA assessed gut microbiota. Results and Discussion: Methyl donor supplementation decreased (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1665-2681 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1665268124004095; https://doaj.org/toc/1665-2681 |
| DOI: |
10.1016/j.aohep.2024.101626 |
| URL الوصول: |
https://doaj.org/article/8e21c9d208ac493f8b9ed1c67598c0c1 |
| رقم الانضمام: |
edsdoj.8e21c9d208ac493f8b9ed1c67598c0c1 |
| قاعدة البيانات: |
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