التفاصيل البيبلوغرافية
| العنوان: |
Risk factors for elevated serum colorectal cancer markers in patients with type 2 diabetes mellitus |
| المؤلفون: |
Guo Jingjing, Wang Bin, Hou Weikai, Ma Kun |
| المصدر: |
Open Life Sciences, Vol 15, Iss 1, Pp 267-273 (2020) |
| بيانات النشر: |
De Gruyter, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
colorectal cancer, carbohydrate antigen, methylated septin9, body mass index, vitamin d, glycated hemoglobin a1c, triglyceride, Biology (General), QH301-705.5 |
| الوصف: |
The study aims to examine the risk factors for increased colorectal cancer (CRC) markers in patients with type 2 diabetes mellitus (T2DM). The 229 patients retrospectively reviewed were categorized into two groups: CRC tumor marker-positive and -negative groups. Patients who tested positive for all three of the following CRC markers were included in the CRC tumor marker-positive group: serum carcinoembryonic antigen, carbohydrate antigen 19-9 and septin9 methylation. Univariate analysis revealed that most CRC marker-positive patients had higher age, a family history of CRC, history of smoking and alcohol intake, high body mass index (BMI; overweight), longer history of T2DM, worse diabetes control (with high glycated hemoglobin A1c [HbA1c]), lower level of serum vitamin D (VD), high-density lipoprotein cholesterol and higher level of total cholesterol and triglyceride (TG). Logistic regression analysis showed that BMI, VD, HbA1c and TG were independent predictors of CRC marker-positive status (OR, 95% confidence intervals and P values were 1.912 [1.346–2.716], |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2391-5412 |
| Relation: |
https://doaj.org/toc/2391-5412 |
| DOI: |
10.1515/biol-2020-0030 |
| URL الوصول: |
https://doaj.org/article/8db8c8fed94d4d409133b138789c2f42 |
| رقم الانضمام: |
edsdoj.8db8c8fed94d4d409133b138789c2f42 |
| قاعدة البيانات: |
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