Academic Journal
Decoding the metastatic potential and optimal postoperative adjuvant therapy of melanoma based on metastasis score
| العنوان: | Decoding the metastatic potential and optimal postoperative adjuvant therapy of melanoma based on metastasis score |
|---|---|
| المؤلفون: | Kangjie Shen, Wenyu Song, Hongye Wang, Lu Wang, Yang Yang, Qianrong Hu, Min Ren, Zixu Gao, Qiangcheng Wang, Shaoluan Zheng, Ming Zhu, Yanwen Yang, Yong Zhang, Chuanyuan Wei, Jianying Gu |
| المصدر: | Cell Death Discovery, Vol 9, Iss 1, Pp 1-14 (2023) |
| بيانات النشر: | Nature Publishing Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Cytology |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
| الوصف: | Abstract Metastasis is a formidable challenge in the prognosis of melanoma. Accurately predicting the metastatic potential of non-metastatic melanoma (NMM) and determining effective postoperative adjuvant treatments for inhibiting metastasis remain uncertain. In this study, we conducted comprehensive analyses of melanoma metastases using bulk and single-cell RNA sequencing data, enabling the construction of a metastasis score (MET score) through diverse machine-learning algorithms. The reliability and robustness of the MET score were validated using various in vitro assays and in vivo models. Our findings revealed a distinct molecular landscape in metastatic melanoma characterized by the enrichment of metastasis-related pathways, intricate cell–cell communication, and heightened infiltration of pro-angiogenic tumor-associated macrophages compared to NMM. Importantly, patients in the high MET score group exhibited poorer prognoses and an immunosuppressive microenvironment, featuring increased infiltration of regulatory T cells and decreased infiltration of CD8+ T cells, compared to the low MET score patient group. Expression of PD-1 was markedly higher in patients with low MET scores. Anti-PD-1 (aPD-1) therapy profoundly affected antitumor immunity activation and metastasis inhibition in these patients. In summary, our study demonstrates the effectiveness of the MET score in predicting melanoma metastatic potential. For patients with low MET scores, aPD-1 therapy may be a potential treatment strategy to inhibit metastasis. Patients with high MET scores may benefit from combination therapies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2058-7716 |
| Relation: | https://doaj.org/toc/2058-7716 |
| DOI: | 10.1038/s41420-023-01678-6 |
| URL الوصول: | https://doaj.org/article/c8d5e95afefb4072ae5616eadb823832 |
| رقم الانضمام: | edsdoj.8d5e95afefb4072ae5616eadb823832 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20587716 |
|---|---|
| DOI: | 10.1038/s41420-023-01678-6 |