التفاصيل البيبلوغرافية
| العنوان: |
Correction of a Factor VIII genomic inversion with designer-recombinases |
| المؤلفون: |
Felix Lansing, Liliya Mukhametzyanova, Teresa Rojo-Romanos, Kentaro Iwasawa, Masaki Kimura, Maciej Paszkowski-Rogacz, Janet Karpinski, Tobias Grass, Jan Sonntag, Paul Martin Schneider, Ceren Günes, Jenna Hoersten, Lukas Theo Schmitt, Natalia Rodriguez-Muela, Ralf Knöfler, Takanori Takebe, Frank Buchholz |
| المصدر: |
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022) |
| بيانات النشر: |
Nature Portfolio, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
Correction of disease-causing large genomic inversions remains challenging. Here, the authors developed a dual designer-recombinase system (RecF8) that efficiently corrects a 140 kb inversion frequently found in patients with severe Hemophilia A. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-28080-7 |
| URL الوصول: |
https://doaj.org/article/8d46d2035aed42e78c73c8d76348317f |
| رقم الانضمام: |
edsdoj.8d46d2035aed42e78c73c8d76348317f |
| قاعدة البيانات: |
Directory of Open Access Journals |
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