التفاصيل البيبلوغرافية
| العنوان: |
Impact of pre-operative abdominal MRI on survival for patients with resected pancreatic carcinoma: a population-based studyResearch in context |
| المؤلفون: |
Amer Alaref, Dylan Siltamaki, Joshua O. Cerasuolo, Noori Akhtar-Danesh, Joseph M. Caswell, Pablo E. Serrano, Brandon M. Meyers, David W. Savage, Jennifer Nelli, Michael Patlas, Abdullah Alabousi, Rabail Siddiqui, Christian B. van der Pol |
| المصدر: |
The Lancet Regional Health. Americas, Vol 35, Iss , Pp 100809- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Public aspects of medicine |
| مصطلحات موضوعية: |
Carcinoma, Pancreatic ductal, Magnetic resonance imaging, Pancreatectomy, Pancreatic neoplasms, Survival analysis, Public aspects of medicine, RA1-1270 |
| الوصف: |
Summary: Background: This study determined the impact of pre-operative abdominal MRI on all-cause mortality for patients with resected PDAC. Methods: All adult (≥18 years) PDAC patients who underwent pancreatectomy between January 2011 and December 2022 in Ontario, Canada, were identified for this population-based cohort study (ICD-O-3 codes: C250, C251, C252, C253, C257, C258). Patient demographics, comorbidities, PDAC stage, medical and surgical management, and survival data were sourced from multiple linked provincial administrative databases at ICES. All-cause mortality was compared between patients with and without a pre-operative abdominal MRI after controlling for multiple covariates. Findings: A cohort of 4579 patients consisted of 2432 men (53.1%) and 2147 women (46.9%) with a mean age of 65.2 years (standard deviation: 11.2 years); 2998 (65.5%) died while 1581 (34.5%) survived. Median follow-up duration post-resection was 22.4 months (interquartile range: 10.8–48.8 months), and median survival post-pancreatectomy was 25.9 months (95% confidence interval [95% CI]: 24.8, 27.5). Patients who underwent a pre-operative abdominal MRI had a median survival of 33.1 months (95% CI: 30.7, 37.2) compared to 21.1 months (95% CI: 19.8, 22.6) for all others. A total of 2354/4579 (51.4%) patients underwent a pre-operative abdominal MRI, which was associated with a 17.2% (95% CI: 11.0, 23.1) decrease in the rate of all-cause mortality, with an adjusted hazard ratio (aHR) of 0.828 (95% CI: 0.769, 0.890). Interpretation: Pre-operative abdominal MRI was associated with improved overall survival for PDAC patients who underwent pancreatectomy, possibly due to better detection of liver metastases than CT. Funding: Northern Ontario Academic Medicine Association (NOAMA) Clinical Innovation Fund. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2667-193X |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2667193X24001364; https://doaj.org/toc/2667-193X |
| DOI: |
10.1016/j.lana.2024.100809 |
| URL الوصول: |
https://doaj.org/article/8d24a49ada20419ab891dd279e1bf5d2 |
| رقم الانضمام: |
edsdoj.8d24a49ada20419ab891dd279e1bf5d2 |
| قاعدة البيانات: |
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