التفاصيل البيبلوغرافية
| العنوان: |
The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo |
| المؤلفون: |
Bodvael Fraysse, Antonella Liantonio, Michela Cetrone, Rosa Burdi, Sabata Pierno, Antonio Frigeri, Michela Pisoni, Claudia Camerino, Annamaria De Luca |
| المصدر: |
Neurobiology of Disease, Vol 17, Iss 2, Pp 144-154 (2004) |
| بيانات النشر: |
Elsevier, 2004. |
| سنة النشر: |
2004 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
Muscular dystrophy, Calcium homeostasis, Mechanical overload, Mdx mouse, Intact muscle fibers, In vivo exercise, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
Chronic exercise in vivo aggravates dystrophy in mdx mice. Calcium homeostasis was evaluated ex vivo by micro-spectrofluorometry on tendon-to-tendon dissected extensor digitorum longus (EDL) muscle fibers. Resting cytosolic calcium ([Ca2+]i) and sarcolemmal permeability through Gd3+-sensitive mechanosensitive calcium (MsCa) channel were significantly higher in mdx vs. wild-type fibers. The exercise further enhanced [Ca2+]i in mdx fibers and increased sarcolemmal permeability by activating nifedipine-sensitive leak calcium channels. The two genotypes did not differ in caffeine sensitivity and in the excitation-calcium release (ECaR) coupling mechanism by K+ depolarization. The exercise produced a similar adaptation of activation curve of ECaR and of sensitivity to caffeine. However, the inactivation of ECaR of mdx fibers did not adapt to exercise. No fiber phenotype transition occurred in exercised muscle. We provide the first evidence that an in vivo exercise worsens the impaired calcium homeostasis of dystrophic fibers, supporting the role of enhanced calcium entrance in dystrophic progression. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1095-953X |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0969996104001317; https://doaj.org/toc/1095-953X |
| DOI: |
10.1016/j.nbd.2004.06.002 |
| URL الوصول: |
https://doaj.org/article/8d171f21b90c4bc7a7a342ce607293eb |
| رقم الانضمام: |
edsdoj.8d171f21b90c4bc7a7a342ce607293eb |
| قاعدة البيانات: |
Directory of Open Access Journals |