التفاصيل البيبلوغرافية
| العنوان: |
The Role of Microglia with Mitochondrial Dysfunction and Its Therapeutic Prospects in Alzheimer's Disease |
| المؤلفون: |
Yuanyuan Li, Tong Li, Tiantian Chen, Chunhua Li, Wenhui Yu, Yunlong Xu, Xuehui Zeng, Fuxiang Zheng |
| المصدر: |
Journal of Integrative Neuroscience, Vol 23, Iss 5, p 91 (2024) |
| بيانات النشر: |
IMR Press, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
alzheimer's disease, microglia, mitochondria, microglia with mitochondrial dysfunction, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
Alzheimer’s disease (AD), a primary cause of dementia, is rapidly emerging as one of the most financially taxing, lethal, and burdensome diseases of the 21st century. Increasing evidence suggests that microglia-mediated neuroinflammation plays a key role in both the initiation and progression of AD. Recently, emerging evidence has demonstrated mitochondrial dysfunction, particular in microglia where precedes neuroinflammation in AD. Multiple signaling pathways are implicated in this process and pharmaceutical interventions are potentially involved in AD treatment. In this review, advance over the last five years in the signaling pathways and pharmaceutical interventions are summarized and it is proposed that targeting the signaling pathways in microglia with mitochondrial dysfunction could represent a novel direction for AD treatment. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
0219-6352 |
| Relation: |
https://www.imrpress.com/journal/JIN/23/5/10.31083/j.jin2305091; https://doaj.org/toc/0219-6352 |
| DOI: |
10.31083/j.jin2305091 |
| URL الوصول: |
https://doaj.org/article/8ce446d306cf451387cacbcd11e2e33c |
| رقم الانضمام: |
edsdoj.8ce446d306cf451387cacbcd11e2e33c |
| قاعدة البيانات: |
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