Academic Journal
Mohawk protects against tendon damage via suppressing Wnt/β-catenin pathway
| العنوان: | Mohawk protects against tendon damage via suppressing Wnt/β-catenin pathway |
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| المؤلفون: | Ziming Liu, Wenfeng Han, Jiao Meng, Yanbing Pi, Tong Wu, Yifei Fan, Qinwei Guo, Xiaoqing Hu, Yuhua Chen, Wenxiao Jiang, Feng Zhao |
| المصدر: | Heliyon, Vol 10, Iss 4, Pp e25658- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Tendon damage, Mkx, Tension strength, Wnt/β-catenin, Mechanical force, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Degenerative tendon injuries are common clinical problems associated with overuse or aging, and understanding the mechanisms of tendon injury and regeneration can contribute to the study of tendon healing and repair. As a transcription factor, Mohawk (Mkx) is responsible for tendons development, yet, the roles of which in tendon damage remain mostly elusive. In this study, using Mkx overexpressed mice on long treadmill as an in vivo model and MkxOE Achilles tenocytes stimulated by equiaxial stretch as an in vitro model, we anaylsed the effects of Mkx overexpression on the tendon. Mkx and tendon tension strength were decreased after the expose to excessive mechanical forces, and Mkx overexpression protected the tendon from damage. Moreover, we revealed that the Wnt/β-catenin activation, inflammation, and Runx2 expression were increased at the injured Achilles tendon, upregulated Mkx significantly reversed the increased Wnt/β-catenin pathway, Tnf-α, Il-1β, and Il-6 levels, and reduced tendon cell damage. However, Wnt3a, IWR and BIO had not significantly affected the Mkx expression in achilles tenocytes. In conclusion, Mkx is involved in tendon healing and protects the tendon from damage through suppressing Wnt/β-catenin pathway, suggesting Mkx/Wnt/β-catenin pathway may be potential therapeutic targets for tendon damage. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S240584402401689X; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e25658 |
| URL الوصول: | https://doaj.org/article/8c98a764cf1e4ba6a2409b18b1872743 |
| رقم الانضمام: | edsdoj.8c98a764cf1e4ba6a2409b18b1872743 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e25658 |