Academic Journal
The Diagnostic Value of the 50-Gram Glucose Challenge Test at Various Cut-off Levels Combined with Clinical Risk Factors in Predicting the Diagnosis of Gestational Diabetes Mellitus
| العنوان: | The Diagnostic Value of the 50-Gram Glucose Challenge Test at Various Cut-off Levels Combined with Clinical Risk Factors in Predicting the Diagnosis of Gestational Diabetes Mellitus |
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| المؤلفون: | Amontis Chaimongkolpipob, Supapen Lertvutivivat, Tongta Nanthakomon, Chamnan Tanprasertkul, Banthisa Somboon, Charintip Somprasit |
| المصدر: | Journal of Health Science and Medical Research (JHSMR), Vol 42, Iss 5, Pp e20241063-e20241063 (2024) |
| بيانات النشر: | Prince of Songkla University, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | 50-gram glucose challenge test, 100-gram oral glucose tolerance test, clinical risk factors, gestational diabetes mellitus diagnosis, Medicine |
| الوصف: | Objective: To evaluate the diagnostic precision of the 50-gram glucose challenge test (50-g GCT) at various levels for the detection of gestational diabetes mellitus (GDM), and to examine its association with clinical risk indicators. Material and Methods: At Thammasat University Hospital, our retrospective cohort comprised 1,197 pregnant women screened using the 50-g GCT based on risk factors, including a family history of GDM, obesity, and other factors. Out of these, 219 tested positive, with 83 (37.9%) diagnosed with GDM and 136 (62.1%) without GDM. Comprehensive data including baseline characteristics, as well as maternal and neonatal outcomes, were compiled. We assessed the correlations between clinical risk factors and 50-g GCT values to ascertain GDM. The positive predictive value (PPV) and negative predictive value (NPV) for various cut-off levels were determined. Results: The best cutoff for the 50-g GCT for GDM diagnosis was ≥220 mg/dL with 100% PPV without adding clinical risk. The PPVs reached 75% and 100%, respectively, when combined with maternal age ≥35 years at 50-g GCT thresholds of ≥210 mg/dL and ≥220 mg/dL. A history of diabetes in the family combined with a 50-g GCT provided 100% PPV at 200 mg/dL. Conclusion: A 50-g GCT cut-off value of ≥220mg/dL is proposed for a definitive GDM diagnosis in certain circumstances, negating the need for this additional test. When a pregnant woman has a family history of diabetes, the 50-g GCT cut-off of 200 mg/dL could be a promising marker for identifying GDM. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2586-9981 2630-0559 |
| Relation: | https://www.jhsmr.org/index.php/jhsmr/article/view/1063; https://doaj.org/toc/2586-9981; https://doaj.org/toc/2630-0559 |
| DOI: | 10.31584/jhsmr.20241063 |
| URL الوصول: | https://doaj.org/article/8c658385bbca4be3b4cf73de23e652a6 |
| رقم الانضمام: | edsdoj.8c658385bbca4be3b4cf73de23e652a6 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 25869981 26300559 |
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| DOI: | 10.31584/jhsmr.20241063 |