التفاصيل البيبلوغرافية
| العنوان: |
Pyoderma gangrenosum following anti-TNF therapy in chronic recurrent multifocal osteomyelitis: drug reaction or cutaneous manifestation of the disease? A critical review on the topic with an emblematic case report |
| المؤلفون: |
Maurizio Romagnuolo, Chiara Moltrasio, Claudia Iannone, Maurizio Gattinara, Stefano Cambiaghi, Angelo Valerio Marzano |
| المصدر: |
Frontiers in Medicine, Vol 10 (2023) |
| بيانات النشر: |
Frontiers Media S.A., 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Medicine (General) |
| مصطلحات موضوعية: |
pyoderma gangrenosum, chronic recurrent multifocal osteomyelitis, drug-induced PG, anti-TNF, adalimumab, adverse drug reaction, Medicine (General), R5-920 |
| الوصف: |
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory disease, clinically characterized by chronic and recurrent episodes of osteoarticular inflammation, that generally presents in children and adolescents. From a dermatological point-of-view, CMRO can be associated with skin rashes mainly including psoriasis, palmoplantar pustulosis and acne. Pyoderma gangrenosum (PG) is a rare immune-mediated inflammatory skin disease classified within the spectrum of neutrophilic dermatoses that, in some cases, has been reported as cutaneous manifestation in CMRO patients. This paper presents a 16-year female patient diagnosed with CMRO, who presented PG lesions located on the lower leg, that arose after the administration of the tumour necrosis factor (TNF)-α inhibitor adalimumab. Cases of PG have been reported in patients being treated with certain medications, including TNF-α antagonists, leading to classified them in a setting aptly termed “drug-induced PG.” In this paper, we discuss the co-occurrence of PG and CRMO, in the light of recent evidence on the pathogenesis of both diseases and giving ample space to a literature review on drug induced PG. In our case, it is plausible that PG could be considered a cutaneous manifestation of CRMO, although the mechanisms underlying this intriguingly relationship remain to be fully unraveled. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-858X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmed.2023.1197273/full; https://doaj.org/toc/2296-858X |
| DOI: |
10.3389/fmed.2023.1197273 |
| URL الوصول: |
https://doaj.org/article/8be96f2b722044e0bca5b903fd3937d5 |
| رقم الانضمام: |
edsdoj.8be96f2b722044e0bca5b903fd3937d5 |
| قاعدة البيانات: |
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