التفاصيل البيبلوغرافية
| العنوان: |
Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation |
| المؤلفون: |
Xiaoming Sun, Yi Shi, Tomohiro Akahoshi, Mamoru Fujiwara, Hiroyuki Gatanaga, Christian Schönbach, Nozomi Kuse, Victor Appay, George F. Gao, Shinichi Oka, Masafumi Takiguchi |
| المصدر: |
Cell Reports, Vol 15, Iss 10, Pp 2279-2291 (2016) |
| بيانات النشر: |
Elsevier, 2016. |
| سنة النشر: |
2016 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
Biology (General), QH301-705.5 |
| الوصف: |
The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A∗24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable CD8+ T cell responses. We combined comprehensive analysis of the T cell receptor repertoire and cross-reactive potential of wild-type or 2F RW8- and RF10-specific CD8+ T cells with peptide-MHC complex stability and crystal structure studies. We find that, by affecting direct and water-mediated hydrogen bond networks within the peptide-MHC complex, the 2F mutation reduces both TCR and HLA binding. This suggests an advantage underlying the evolution of the 2F variant with decreased CD8+ T cell efficacy. Our study provides a refined understanding of HIV-1 and CD8+ T cell co-adaptation at the population level. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2211-1247 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S221112471630585X; https://doaj.org/toc/2211-1247 |
| DOI: |
10.1016/j.celrep.2016.05.017 |
| URL الوصول: |
https://doaj.org/article/8bc8c09c146b4a2bb6ee5e7745395bca |
| رقم الانضمام: |
edsdoj.8bc8c09c146b4a2bb6ee5e7745395bca |
| قاعدة البيانات: |
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