Academic Journal
The role of canagliflozin in the prevention of stroke and chronic kidney disease in patients with type 2 diabetes mellitus: an expert council resolution
| العنوان: | The role of canagliflozin in the prevention of stroke and chronic kidney disease in patients with type 2 diabetes mellitus: an expert council resolution |
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| المؤلفون: | M. V. Shestakova, G. R. Galstyan, E. N. Grineva, A. V. Zilov, T. Yu. Demidova, A. M. Mkrtumyan, N. A. Petunina, L. A. Ruyatkina, O. Y. Sukhareva, L. A. Suplotova, M. S. Shamkhalova |
| المصدر: | Сахарный диабет, Vol 26, Iss 5, Pp 484-491 (2023) |
| بيانات النشر: | Endocrinology Research Centre, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Nutritional diseases. Deficiency diseases |
| مصطلحات موضوعية: | canagliflozin, isglt-2, sglt-1, type 2 diabetes, stroke, albuminuria, microalbuminuria, macroalbuminuria, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Over the past 10 years of studying the complications of type 2 diabetes mellitus (DM) and ways to deal with them, significant progress has been made in one of the most important areas of treatment — the prevention of cardiovascular and renal complications. Thus, when using inhibitors of type 2 sodium-glucose cotransporter, a significant reduction in the risks of cardiovascular mortality and progression of chronic heart failure, which occupy the main place in the structure of mortality in this cohort of patients, as well as a positive effect on diabetic nephropathy, one of the most common complications of type 2 diabetes, has been proven. However, there are other complications that significantly affect the duration and quality of life of patients. In particular, these include stroke, which occupies the 2nd-3rd place in the frequency of death of people with type 2 diabetes, and albuminuria, a frequent manifestation of diabetic kidney disease, which is associated with an increased risk of cardiovascular complications (including stroke) and chronic renal failure. Recent studies indicate the important role of sodium-glucose cotransporter type 1 in the development of these complications. Canagliflozin has the highest affinity for these transporters among iSGLT-2 registered in the Russian Federation. This article aims to evaluate the mechanisms of action of canagliflozin and its possible role in the prevention of stroke and albuminuria. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Russian |
| تدمد: | 2072-0351 2072-0378 |
| Relation: | https://www.dia-endojournals.ru/jour/article/view/13086; https://doaj.org/toc/2072-0351; https://doaj.org/toc/2072-0378 |
| DOI: | 10.14341/DM13086 |
| URL الوصول: | https://doaj.org/article/cc8bbcd485854342af83849fedacb388 |
| رقم الانضمام: | edsdoj.8bbcd485854342af83849fedacb388 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 20720351 20720378 |
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| DOI: | 10.14341/DM13086 |