Academic Journal
Similarity between the association factor of ribosomal subunits and the protein Stm1p from Saccharomyces cerevisiae
| العنوان: | Similarity between the association factor of ribosomal subunits and the protein Stm1p from Saccharomyces cerevisiae |
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| المؤلفون: | Heriberto Correia, Rafael Medina, Alexandra Hernández, Ekaterina Bustamante, Kalpana Chakraburtty, Flor Herrera |
| المصدر: | Memorias do Instituto Oswaldo Cruz, Vol 99, Iss 7, Pp 733-737 (2004) |
| بيانات النشر: | Fundação Oswaldo Cruz (FIOCRUZ), 2004. |
| سنة النشر: | 2004 |
| المجموعة: | LCC:Microbiology LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | ribosomal association factor, Stm1p, G4 DNA, ribosomal function, G4p2, triplex-DNA, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216 |
| الوصف: | A ribosome association factor (AF) was isolated from the yeast Sacchharomyces cerevisiae. Partial amino acid sequence of AF was determined from its fragment of 25 kDa isolated by treating AF with 2-(2-nitrophenylsulfenyl)-3-methyl-3'-Bromoindolenine (BNPS-skatole). This sequence has a 86% identity to the product of the single-copy S. cerevisiae STM1 gene that is apparently involved in several events like binding to quadruplex and triplex nucleic acids and participating in apoptosis, stability of telomere structures, cell cycle, and ribosomal function. Here we show that AF and Stm1p share some characteristics: both bind to quadruplex and Pu triplex DNA, associates ribosomal subunits, and are thermostable. These observations suggest that these polypeptides belong to a family of proteins that may have roles in the translation process. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0074-0276 1678-8060 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000700012; https://doaj.org/toc/0074-0276; https://doaj.org/toc/1678-8060 |
| DOI: | 10.1590/S0074-02762004000700012 |
| URL الوصول: | https://doaj.org/article/c8b643f53b6844c5a3fcbeb7cb979fc7 |
| رقم الانضمام: | edsdoj.8b643f53b6844c5a3fcbeb7cb979fc7 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 00740276 16788060 |
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| DOI: | 10.1590/S0074-02762004000700012 |