Academic Journal
Temporal lobe white matter pathways: clinical and anatomical examination related to surgery of drug-resistant structural focal epilepsy
| العنوان: | Temporal lobe white matter pathways: clinical and anatomical examination related to surgery of drug-resistant structural focal epilepsy |
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| المؤلفون: | A. A. Sufianov, I. S. Shelyagin, K. Simfukwe, E. S. Markin, S. Zh. Stefanov, Yu. A. Yakimov, P. O. Akimova, R. A. Sufianov |
| المصدر: | Эпилепсия и пароксизмальные состояния, Vol 14, Iss 3, Pp 242-253 (2022) |
| بيانات النشر: | IRBIS LLC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | drug-resistant epilepsy, temporal lobe focal cortical dysplasia, brain pathways, anterior temporal lobectomy, multidisciplinary approach, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Background. Detected temporal lobe focal cortical dysplasia (FCD) often results in developing drug-resistant epilepsy requiring surgical treatment. In turn, temporal lobectomy, despite its high efficiency, can cause a certain deficit associated with direct or indirect damage to the brain pathways.Objective: to describe the main anatomical features of temporal lobe brain pathways and clinical outcomes of surgical treatment of drug-resistant epilepsy that developed in temporal lobe FCD.Material and methods. A retrospective analysis of the treatment of 14 patients with drug-resistant structural focal epilepsy (temporal lobe FCD) who underwent surgery (anterior temporal lobectomy) was carried out. To localize the epileptogenic zone, specialists of the multidisciplinary group performed a comprehensive presurgical examination in all participants. The surgical material was examined by a neuromorphologist, the diagnosis was verified. In the postoperative period, patients underwent a series of control examinations at standard time points (after 3, 6, 12, 36 months). The minimum follow-up period was 12 months. As a part of the anatomical study, 6 brain hemispheres were investigated prepared for the white matter fibers dissection using Klingler technique. The main pathways that run within or near the temporal lobe were selectively examined: the lower longitudinal, medial longitudinal, lower fronto-occipital and uncinate fasciculi.Results. In the postoperative period, no complications were observed in 14.3% of patients after 4 cm resection of the temporal lobe subdominant hemisphere. Speech disorders (mostly transient) were detected in 35.7% of the subjects, visual field disorders (mainly transient) – in 21.4%, neuropsychiatric disorders – in 43.9%. Overall seizure control: 93% of patients achieved class I according to Engel Epilepsy Surgery Outcome Scale.Conclusion. Anterior temporal lobectomy can be considered as a highly effective method of surgical treatment of drug-resistant structural focal epilepsy with a high rate of achieving control over epileptic seizures in the postoperative period. However, the mandatory conditions for maintaining the quality of life for patients after such a surgical intervention include preoperative analysis of the risk of adverse effects performed by a multidisciplinary team as well as postoperative management and rehabilitation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 2077-8333 2311-4088 |
| Relation: | https://www.epilepsia.su/jour/article/view/820; https://doaj.org/toc/2077-8333; https://doaj.org/toc/2311-4088 |
| DOI: | 10.17749/2077-8333/epi.par.con.2022.126 |
| URL الوصول: | https://doaj.org/article/8b03e6f7acf3444eb414d79664ec248b |
| رقم الانضمام: | edsdoj.8b03e6f7acf3444eb414d79664ec248b |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 20778333 23114088 |
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| DOI: | 10.17749/2077-8333/epi.par.con.2022.126 |