التفاصيل البيبلوغرافية
| العنوان: |
High Levels of IL-10 and CD4+CD25hi+ Treg Cells in Endemic Burkitt’s Lymphoma Patients |
| المؤلفون: |
Godfred Futagbi, Ben Gyan, Harriet Nunoo, John K.A. Tetteh, Jennifer E. Welbeck, Lorna Awo Renner, Michael Ofori, Daniel Dodoo, Dominic A. Edoh, Bartholomew D. Akanmori |
| المصدر: |
Biomedicines, Vol 3, Iss 3, Pp 224-236 (2015) |
| بيانات النشر: |
MDPI AG, 2015. |
| سنة النشر: |
2015 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
Burkitt’s lymphoma, malaria, EBNA1, Th2, Treg cells, Biology (General), QH301-705.5 |
| الوصف: |
Background: The interplay between Epstein-Barr virus infection, malaria, and endemic Burkitt’s Lymphoma is not well understood. Reports show diminished EBV-specific Th1 responses in children living in malaria endemic areas and deficiency of EBNA1-specific IFN-γ T cell responses in children with endemic Burkitt’s Lymphoma (eBL). This study, therefore, examined some factors involved in the loss of EBNA-1-specific T cell responses in eBL. Methods: T-cell subset frequencies, activation, and IFN-γ- or IL-4-specific responses were analyzed by flow-cytometry. Plasma cytokine levels were measured by ELISA. Results: CD4+ and CD8+ cells in age- and sex-matched healthy controls (n = 3) expressed more IFN-γ in response to all immunostimulants than in pediatric endemic BL (eBL) patients (n = 4). In healthy controls, IFN-γ expression was higher than IL-4 expression, whereas in eBL patients the expression of IL-4 by CD4+ cells to EBNA-1 was slightly higher than IFN-γ. Moreover, the blood levels of TNF-α was significantly lower (p = 0.004) while IL-10 was significantly higher (p = 0.038), in eBL patients (n = 21) compared to controls (n = 16). Additionally, the frequency of CD4+CD25hi+ T cells was higher in both age-matched acute uncomplicated malaria (n = 26) and eBL (n = 14) patients compared to healthy controls (n = 19; p = 0.000 and p = 0.027, respectively). Conclusion: The data suggest that reduced Th1 response in eBL might be due to increased levels of IL-10 and T reg cells. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2227-9059 |
| Relation: |
http://www.mdpi.com/2227-9059/3/3/224; https://doaj.org/toc/2227-9059 |
| DOI: |
10.3390/biomedicines3030224 |
| URL الوصول: |
https://doaj.org/article/8afc7252378840ea89fea57f1267b09b |
| رقم الانضمام: |
edsdoj.8afc7252378840ea89fea57f1267b09b |
| قاعدة البيانات: |
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