Academic Journal
LRRK2 G2019S Mutation: Prevalence and Clinical Features in Moroccans with Parkinson’s Disease
| العنوان: | LRRK2 G2019S Mutation: Prevalence and Clinical Features in Moroccans with Parkinson’s Disease |
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| المؤلفون: | Ahmed Bouhouche, Houyam Tibar, Rafiqua Ben El Haj, Khalil El Bayad, Rachid Razine, Sanaa Tazrout, Asmae Skalli, Naima Bouslam, Loubna Elouardi, Ali Benomar, Mohammed Yahyaoui, Wafa Regragui |
| المصدر: | Parkinson's Disease, Vol 2017 (2017) |
| بيانات النشر: | Hindawi Limited, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Background. The LRRK2 G2019S mutation is the most common genetic determinant of Parkinson’s disease (PD) identified to date. This mutation, reported in both familial and sporadic PD, occurs at elevated frequencies in Maghreb population. In the present study, we examined the prevalence of the G2019S mutation in the Moroccan population and we compared the motor and nonmotor phenotype of G2019S carriers to patients with idiopathic Parkinson’s disease. Methods. 100 PD patients were assessed for motor and nonmotor symptoms, current medication, and motor complication including motor fluctuations and dyskinesia. The LRRK2 G2019S mutation was investigated by direct sequencing in patients and ethnically matched controls, all of Moroccan origin. Results. Among the 100 PD Moroccan patients, 41 (41%) were carriers of the G2019S mutation. The mutation frequency was higher among probands with autosomal dominant inheritance (76%) than among sporadic ones (28%). Interestingly, G2019S mutation was also found in 5% of control individuals. Clinically, patients carrying the G2019S mutation have more dystonia (OR = 4.6, p = 0.042) and more sleep disorders (OR = 2.4, p = 0.045) than noncarriers. Conclusions. The LRRK2 G2019S prevalence in Morocco is the highest in the world reported to date. Some clinical features in G2019S carriers such as dystonia and sleep disturbances are worth noting. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-8083 2042-0080 |
| Relation: | https://doaj.org/toc/2090-8083; https://doaj.org/toc/2042-0080 |
| DOI: | 10.1155/2017/2412486 |
| URL الوصول: | https://doaj.org/article/8adb26575b174d94aee5d9a5851268ea |
| رقم الانضمام: | edsdoj.8adb26575b174d94aee5d9a5851268ea |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20908083 20420080 |
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| DOI: | 10.1155/2017/2412486 |