التفاصيل البيبلوغرافية
| العنوان: |
Proper micro-environment alleviates mortality in laboratory mouse breeding induced by litter overlap and older dams |
| المؤلفون: |
Gabriela M. Morello, Sara Capas-Peneda, Sophie Brajon, Sofia Lamas, Igor M. Lopes, Colin Gilbert, I. Anna S. Olsson |
| المصدر: |
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024) |
| بيانات النشر: |
Nature Portfolio, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
Biology (General), QH301-705.5 |
| الوصف: |
Abstract The ongoing worldwide effort to reduce animal numbers in research often omits the issue of pre-weaning mortality in mouse breeding. A conservative estimate of 20% mortality would mean approximately 1.1 M mice die annually in the EU before scientific use. We hypothesize that pre-weaning mortality in laboratory mouse breeding is associated with cage social and macro/micro-environment conditions. Here we count pups from 509 C57BL/6J litters daily for accurate detection of mortality, and monitor cage micro-environment for 172 C57BL/6J litters. Probability of pups to die increases with the increase in dam age, number and age of older pups in the cage (of overlapped/cohabitating litters), and in small (11 pups) focal litters. Higher temperatures (>23.6 °C) and nest scores (>3.75) compensate for some of the socially-associated risks for pup death. These findings can be implemented in strategies for reducing pre-weaning mouse mortality, a more welfare-friendly and sustainable approach for science. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2399-3642 |
| Relation: |
https://doaj.org/toc/2399-3642 |
| DOI: |
10.1038/s42003-024-06654-z |
| URL الوصول: |
https://doaj.org/article/8ac4d94348884ebab2036e1a52ae9705 |
| رقم الانضمام: |
edsdoj.8ac4d94348884ebab2036e1a52ae9705 |
| قاعدة البيانات: |
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